ArticleArteriosclerosis, thrombosis, and vascular biology2022
Gut Microbiota, Plasma Metabolomic Profiles, and Carotid Artery Atherosclerosis in HIV Infection.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31citing papers in PubMed, 1 pooled it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Multi-omics analysis of the gut microbiome and carotid artery atherosclerosis in men with and without HIV.EBioMedicine · 2026Article
- The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Lysophosphatidylethanolamine (LysoPE) in health and disease: a narrative review of its pathophysiological mechanisms and translational potential as a biomarker.Frontiers in cell and developmental biology · 2026Review
- Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications.Caspian journal of internal medicine · 2026Review
- Gut Microbiota and Atherosclerosis: Integrative Multi-Omics and Mechanistic Insights.Current atherosclerosis reports · 2025Review
- Investigation of ED4 supplementation on cardiovascular parameters in rats with elevated systemic TMAO.NPJ science of food · 2025Article
- Thrombotic and cardiovascular events in HIV infection (Review).Biomedical reports · 2025Review
- Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2025Article
- The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 1-Deoxynojirimycin with theaflavins ameliorates high-fat diet-induced insulin resistance in mice by modulating the gut microbiota.Frontiers in nutrition · 2025Article
- The Oral Microbiota, Microbial Metabolites, and Immuno-Inflammatory Mechanisms in Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Gut Microbiome and Carotid Artery Intima-Media Thickness: A Narrative Review of the Current Scenario.Diagnostics (Basel, Switzerland) · 2024Review
- Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles.Journal of pharmaceutical analysis · 2024Article
- Major depletion of insulin sensitivity-associated taxa in the gut microbiome of persons living with HIV controlled by antiretroviral drugs.BMC medical genomics · 2024Article
- Review
- Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease.Circulation research · 2024Review
- Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection.Genome medicine · 2024Article
- Distinct Lipidomic Profiles between People Living with HIV Treated with E/C/F/TAF or B/F/TAF: An Open-Label Prospective Cohort Study.Infectious diseases and therapy · 2024Article
Corrections and comments
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Authors and funding
26 authors at 14 institutions in 2 countries.
Zheng WangDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
Brandilyn A PetersDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.ORCID 0000-0002-1534-2578
Mykhaylo UsykDepartment of Pediatrics (M.U., R.D.B.), Albert Einstein College of Medicine, Bronx, New York.
Jiaqian XingDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
David B HannaDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
Tao WangDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
Wendy S PostDepartment of Medicine, Johns Hopkins University, Baltimore, MD (W.S.P.).ORCID 0000-0002-8655-5204
Alan L LandayDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL (A.L.L).
Howard N HodisAtherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles (H.N.H.).
Kathleen WeberHektoen Institute of Medicine, Chicago, IL (K.W.).
Audrey FrenchDepartment of Internal Medicine, John H. Stroger Jr Hospital of Cook County, Chicago, IL (A.F.).
Elizabeth T GolubDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.T.G., S.H.).
Jason LazarDepartment of Medicine (J.L.), State University of New York Downstate Medical Center, Brooklyn.
Deborah GustafsonDepartment of Neurology (D.G.), State University of New York Downstate Medical Center, Brooklyn.
Seble KassayeDepartment of Medicine, Georgetown University, Washington DC (S.K.).
Bradley AouizeratCollege of Dentistry, New York University (B.A.).
Sabina HaberlenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.T.G., S.H.).ORCID 0000-0002-9467-3454
Carlos MalvestuttoWexner Medical Center, Ohio State University, Columbus (C.M.).ORCID 0000-0003-3156-2965
Matthew BudoffDavid Geffen School of Medicine, University of California, Los Angeles (M.B.).ORCID 0000-0002-9616-1946
Steven M WolinskyDepartment of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL (S.M.W.).
Anjali SharmaDepartment of Medicine (A.S., K.A.), Albert Einstein College of Medicine, Bronx, New York.
Kathryn AnastosDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA (C.B.C.).ORCID 0000-0001-8259-9245
Robert C KaplanDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.ORCID 0000-0003-1571-4615
Robert D BurkDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.
Qibin QiDepartment of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York.ORCID 0000-0002-2687-1758
Albert Einstein College of Medicine · USJohns Hopkins University · USBroad Institute · USGeorgetown University · USHektoen Institute · USJohn H. Stroger, Jr. Hospital of Cook County · USNorthwestern University · USRush University Medical Center · USState University of New York · USSUNY Downstate Health Sciences University · USThe Ohio State University Wexner Medical Center · USUniversity of California, Los Angeles · USUniversity of Southern California · USYork College, City University of New York · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MWORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Renee A. Heffron · 1988 to 2026
$84.1MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MWomen's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7MQAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7MWomen's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5MSF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3MSex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8MUniversity of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8MNCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NCI NIH HHS P30 CA013330NHLBI NIH HHS K01 HL129892NHLBI NIH HHS R01 HL083760NHLBI NIH HHS R01 HL095140NHLBI NIH HHS R01 HL126543NHLBI NIH HHS R01 HL132794NHLBI NIH HHS R01 HL140976NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI124414NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI035004NIDDK NIH HHS P30 DK040561NIMHD NIH HHS R01 MD011389NIMH NIH HHS P30 MH116867
Abstract
backgroundAlterations in gut microbiota and blood metabolomic profiles have been implicated in HIV infection and cardiovascular disease. However, it remains unclear whether alterations in gut microbiota may contribute to disrupted host blood metabolomic profiles in relation to atherosclerosis, especially in the context of HIV infection.
methodsWe analyzed cross-sectional associations between gut microbiota features and carotid artery plaque in 361 women with or at high risk of HIV (67% HIV+), and further integrated plaque-associated microbial features with plasma lipidomic/metabolomic profiles. Furthermore, in 737 women and men, we examined prospective associations of baseline gut bacteria-associated lipidomic and metabolomic profiles with incident carotid artery plaque over 7-year follow-up.
resultsWe found 2 potentially pathogenic bacteria,
conclusionsAmong individuals with or at high risk of HIV infection, we identified altered gut microbiota and related functional capacities in the lipid metabolism associated with disrupted plasma lipidomic profiles and carotid artery atherosclerosis.
Indexed as
AtherosclerosisCarotid Artery DiseasesCarotid StenosisGastrointestinal MicrobiomeHIV InfectionsPlaque, AtheroscleroticCarotid ArteriesCross-Sectional StudiesFemaleHumansLysophosphatidylcholinesMaleLysophosphatidylcholinesatherosclerosiscardiovascular diseasesdiglycerideslipid metabolismlipidomics
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