ArticleJDR clinical and translational research2023
A Prospective Longitudinal Study of Early Childhood Caries Onset in Initially Caries-Free Children.
Article in JDR clinical and translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Adverse Childhood Experiences in the First 1000 Days of Life and Dental Caries Experience From Age 31 to 61 Months.Journal of public health dentistry · 2025Article
- Associations Between Diet, Oral Health, and General Development in Romanian School-Age Children.Nutrients · 2025Article
- Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.Cureus · 2024Review
- Article
- Early childhood caries prevention through a developmental origins model of the oral microbiome, host and oral environment, and sociodemographic influences.Quintessence international (Berlin, Germany : 1985) · 2023Article
- Administration of Clinical COVID-19 Mouthwashing Protocol and Potential Modulation of Pediatric Oral Bacterial Prevalence ofPediatric reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionEarly childhood caries (ECC) is a complex oral disease that is prevalent in US children.
objectivesThe purpose of this 2-y prospective cohort study was to examine baseline and time-dependent risk factors for ECC onset in initially caries-free preschool children.
methodsA cohort of 189 initially caries-free children aged 1 to 3 y was recruited. At each 6-mo study visit, children were examined using the ICDAS index; salivary samples were collected to assess mutans streptococci (MS), lactobacilli,
resultsOnset of ECC was associated with high salivary MS levels at baseline (log-rank test,
conclusionOur results provide prospective evidence that an increase in salivary MS predicts ECC onset in young, initially caries-free children, confirming that a high salivary MS count likely plays a causal role in ECC onset, independent of covariates. KNOWLEDGE TRANSFER STATEMENT: These results suggest that we must focus on reducing salivary MS counts in young children and preventing or delaying MS colonization in infants and young children determined to be at risk for ECC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.