ArticleJournal of dental research2022
Systemic Multimorbidity Clusters in People with Periodontitis.
Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The impact of study factors in the association of periodontal disease and cognitive disorders: systematic review and meta-analysis.Age and ageing · 2023Pooled it
- A Network-Medicine Framework for Intra-Oral Comorbidity: Age-Stratified Clustering and Quasi-Causal Progression Modeling from Outpatient Electronic Health Records.Bioengineering (Basel, Switzerland) · 2026Article
- Patterns of multimorbidity and their association with edentulism: the moderating role of health literacy in the Lifelines Cohort.European journal of public health · 2026Article
- Periodontal Medicine: The Past, the Present, the Future.Journal of periodontal research · 2025Article
- Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia.Journal of clinical periodontology · 2025Article
- Multimorbidity patterns and prevalence among geriatric patients in Japanese hospital dentistry.BMC geriatrics · 2025Article
- Presumed periodontitis and multimorbidity patterns: a prospective cohort study in the UK Biobank.Clinical oral investigations · 2025Article
- Age at menopause and multimorbidity in postmenopausal women.Przeglad menopauzalny = Menopause review · 2025Article
- Association between sleep quality and MCI in older adult patients with multimorbidity.Frontiers in public health · 2025Article
- The Prevalence of Comorbidities in Individuals with Periodontitis in a Private Periodontal Referral Practice.Journal of clinical medicine · 2024Article
- Higher Prevalence of Tooth Loss in People With Abdominal Obesity but Normal Weight: Findings From the United States and Scottish Populations.Clinical and experimental dental research · 2024Article
- Multimorbidity Patterns and Periodontal Diseases in a French Hospital-Based Dental School: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Association between toothbrushing behavior and cardiometabolic multimorbidity among middle aged and older adults in North China: a cross-section study.BMC oral health · 2024Article
- Periodontal disease: A systemic condition.Periodontology 2000 · 2024Review
- Systemic Immune-Inflammation Index and Systemic Inflammation Response Index are Associated With Periodontitis: Evidence From NHANES 2009 to 2014.International dental journal · 2024Article
- Inflammation indices in association with periodontitis and cancer.Periodontology 2000 · 2024Review
- The Molecular Comorbidity Network of Periodontal Disease.International journal of molecular sciences · 2024Article
- Independent and combined effects of smoking, drinking and depression on periodontal disease.BMC oral health · 2024Article
- Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper.Frontiers in psychiatry · 2024Article
- A scoping review of the clinical application of machine learning in data-driven population segmentation analysis.Journal of the American Medical Informatics Association : JAMIA · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to identify systemic multimorbidity clusters in people with periodontitis via a novel artificial intelligence-based network analysis and to explore the effect of associated factors. This study utilized cross-sectional data of 3,736 participants across 3 cycles of the National Health and Nutrition Examination Survey (2009 to 2014). Periodontal examination was carried out by trained dentists for participants aged ≥30 y. The extent of periodontitis was represented by the proportion of sites with clinical attachment loss (CAL)≥ 3 mm, split into 4 equal quartiles. A range of systemic diseases reported during the survey were also extracted. Hypergraph network analysis with eigenvector centralities was applied to identify systemic multimorbidity clusters and single-disease influence in the overall population and when stratified by CAL quartile. Individual factors that could affect the systemic multimorbidity clusters were also explored by CAL quartile. In the study population, the top 3 prevalent diseases were hypertension (63.9%), arthritis (47.6%), and obesity (45.9%). A total of 106 unique systemic multimorbidity clusters were identified across the study population. Hypertension was the most centralized disease in the overall population (centrality [C]: 0.50), followed closely by arthritis (C: 0.45) and obesity (C: 0.42). Diabetes had higher centrality in the highest CAL quartile (C: 0.31) than the lowest (C: 0.26). "Hypertension, obesity" was the largest weighted multimorbidity cluster across CAL quartiles. This study has revealed a range of common systemic multimorbidity clusters in people with periodontitis. People with periodontitis are more likely to present with hypertension and obesity together, and diabetes is more influential to multimorbidity clusters in people with severe periodontitis. Factors such as ethnicity, deprivation, and smoking status may also influence the pattern of multimorbidity clusters.
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