ArticleFrontiers in psychiatry2022
Altered Intrinsic Brain Activity in Patients With Late-Life Depression: A Resting-State Functional MRI Study.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in late-life depression: a meta-analysis of resting-state functional imaging studies.Translational psychiatry · 2026Pooled it
- Altered Intrinsic Brain Activity in Ischemic Stroke Patients Assessed Using the Percent Amplitude of a Fluctuation Method.Brain topography · 2024Article
- Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis.Geriatrics (Basel, Switzerland) · 2024Review
- Vulnerable brain regions in adolescent major depressive disorder: A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis.World journal of psychiatry · 2024Article
- Disrupted emotion regulation and spontaneous neural activity in panic disorder: a resting-state fMRI study.Therapeutic advances in psychopharmacology · 2024Article
- Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment.Frontiers in aging neuroscience · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To investigate the altered intrinsic brain activity (IBA) in patients suffering from late-life depression (LLD) using a percent amplitude of fluctuation (PerAF) method. Methods: In total, fifty patients with LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test and resting-state functional MRI (rs-fMRI) scans. The RBANS test consists of 12 sub-tests that contribute to a total score and index scores across the following five domains: immediate memory, visuospatial/constructional, language, attention, and delayed memory. The PerAF method was used for data analysis to detect changes in neural activity in the relevant brain regions. A receiver operating characteristic (ROC) curve was conducted to evaluate the ability of the RBANS test and proposed the PerAF method in distinguishing the two groups. The relationships between altered IBA and neuropsychologic deficits were determined by the Pearson correlation analysis. Results: A significant difference existed in RBANS total score, immediate memory, visuospatial/constructional, language, attention, and delayed memory between groups ( Conclusion: The changes of PerAF in the bilateral Frontal_Sup_Orb and bilateral ACC are related to an increased risk of developing LLD. Moreover, the PerAF method could be used as an underlying sensitivity biomarker to identify the psychiatric disorder.
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