ArticleFrontiers in cardiovascular medicine2022
Cardiac Adaptation to Prolonged High Altitude Migration Assessed by Speckle Tracking Echocardiography.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 9 citations in OpenAlex.
- DNA methylation-mediated regulation of hypoxia-responsive genes facilitates high-altitude adaptation in Tibetan chickens.Poultry science · 2026Article
- Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.Experimental physiology · 2026Review
- Quantitative MRI Values for Atrial and Ventricular Parameters in Altitude-Dwelling Youth.Journal of magnetic resonance imaging : JMRI · 2026Article
- Investigation into the efficacy of fully automated three-dimensional echocardiographic quantification software (3D Auto RV) for assessing right ventricular systolic function in patients suffering from chronic mountain sickness.Frontiers in cardiovascular medicine · 2026Article
- High altitudes, deeper insights: multicenter cardiovascular magnetic resonance study on hypertrophic cardiomyopathy.European radiology · 2025Article
- A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.bioRxiv : the preprint server for biology · 2024Article
- The impact of high-altitude migration on cardiac structure and function: a 1-year prospective study.Frontiers in physiology · 2024Article
- Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude.Cell stress & chaperones · 2023Article
- Effect of ubiquinol on cardiorespiratory fitness during high-altitude acclimatization and de-acclimatization in healthy adults: the Shigatse CARdiorespiratory fitness study design.Frontiers in cardiovascular medicine · 2023Article
- The cardiovascular system and high-altitude exposure: from adaptation to disease. Part I.Archivos peruanos de cardiologia y cirugia cardiovascularArticle
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Exposure to high altitudes represents physiological stress that leads to significant changes in cardiovascular properties. However, long-term cardiovascular adaptions to high altitude migration of lowlanders have not been described. Accordingly, we measured changes in cardiovascular properties following prolonged hypoxic exposure in acclimatized Han migrants and Tibetans. Methods: Echocardiographic features of recently adapted Han migrant (3-12 months, Results: Short-term acclimatized migrants showed increased estimated pulmonary artery systolic pressure (PASP) (32.6 ± 5.1 mmHg vs. 21.1 ± 4.2 mmHg, Conclusion: Right ventricular systolic function is impaired in recent (<1 year) migrants to high altitudes but improved during the long-term dwelling. LV remodeling persists in long-term migrants (>5 years) but without impairment of LV systolic or diastolic function. In contrast, cardiac size, structure, and function of native Tibetans are more similar to those of lowland dwelling Hans.
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