Evidence map›Paper›PMID 35677501›Full record

ArticleJournal of clinical and experimental hepatology

High Prevalence of Hormonal Changes and Hepatic Osteodystrophy in Frail Patients with Cirrhosis-An Observational Study.

Surender Singh, Sunil Taneja, Puneeta Tandon, Arka De, Nipun Verma, Madhumita Premkumar, Ajay Duseja, Radha Krishan Dhiman, Virendra Singh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Longitudinal changes in bone mineral density may be associated with long-term survival in patients with cirrhosis: A proof of concept of study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Trial
  2. Review
  3. Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  4. [Research progress on the correlation between cirrhosis and frailty].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Surender SinghDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Sunil TanejaDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Puneeta TandonDivision of Gastroenterology, University of Alberta, Edmonton, Canada.
Arka DeDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Nipun VermaDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Madhumita PremkumarDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Ajay DusejaDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Radha Krishan DhimanDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Virendra SinghDepartment of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Post Graduate Institute of Medical Education and Research · INUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: Hormonal changes and hepatic osteodystrophy are less often studied complications of cirrhosis. This study describes the variance in hormones and osteodystrophy between Frail and Not frail patients with cirrhosis. Methods: 116 outpatients with cirrhosis were prospectively enrolled in this study. Frailty assessment was done using Liver Frailty Index (LFI). Sociodemographic assessment, anthropometry, nutritional assessment, hormone profile, and dual-energy X-ray absorptiometry scan were done in all patients. Results: 116 patients, predominantly males (100 (86.2%) with mean age of 50.16 years (95% CI, 48.43-51.89) were included. Malnutrition was more common in Frail group as compared to Not frail group. Subjective global assessment (SGA) class-B patients were significantly more in Frail group (37 (74%) vs 3 (4.5%), Conclusion: This is the first study that highlights the high prevalence of hormonal changes and hepatic osteodystrophy in frail patients with cirrhosis and opens a new dimension for research and target of therapy in this field.

Indexed as

ANOVA, analysis of varianceBMD, bone mineral densityBMI, body mass indexCI, confidence intervalcirrhosisCRP, C-reactive proteinCTP, Child–Turcotte–PughDEXA, dual-energy X-ray absorptiometryESR, erythrocyte sedimentation ratefrailtyHCC, hepatocellular carcinomaHE, hepatic encephalopathyhormonal changesIBM, International Business MachinesLFI, Liver Frailty IndexMAC, mid-arm circumferenceMAMC, mid-arm muscle circumferenceMELD, model for end-stage liver diseaseMELDNa, model for end-stage liver disease with sodiumNASH, non-alcoholic steatohepatitisosteodystrophyP1-NP, procollagen type 1 N-terminal propeptidePTH, parathyroid HormoneSGA, subjective global assessmentSPSS, Statistical Package for Social SciencesT3, triiodothyronineT4, tetraiodothyronineTIBC, total iron-binding capacityTSF, triceps skin-fold thicknessTSH, thyroid stimulating hormone

Identifiers

PMID35677501
PMCPMC9168697
OpenAlexW3215324981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.