Evidence map›Paper›PMID 35677079›Full record

ArticlebioRxiv : the preprint server for biology2022

Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins.

Vikas Chonira, Young Do Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Vikas Chonira
Young Do Kwon
Jason Gorman
James Brett Case
Zhiqiang Ku
Rudo Simeon
Ryan G Casner
Darcy R Harris
Adam S Olia
Tyler Stephens
Lawrence Shapiro
Hannah Boyd
Yaroslav Tsybovsky
Florian Krammer
Michael S Diamond
Peter D Kwong
Zhiqiang An
Zhilei Chen

Funding

Artificial Ecology Sink as prophylaxis against viral infectionDP2AI136600 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHEN, ZHILEI · 2017 to 2017
$2.2M
NIAID NIH HHS DP2 AI136600
6 · The paper itself

Abstract

We report the engineering and selection of two synthetic proteins - FSR16m and FSR22 - for possible treatment of SARS-CoV-2 infection. FSR16m and FSR22 are trimeric proteins composed of DARPin SR16m or SR22 fused with a T4 foldon and exhibit broad spectrum neutralization of SARS-Cov-2 strains. The IC

Identifiers

PMID35677079
PMCPMC9176645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.