Evidence map›Paper›PMID 35677076›Full record

ArticleResearch square2022

RNA polymerase inaccuracy underlies SARS-CoV-2 variants and vaccine heterogeneity.

Catherine C Bradley, Alasdair J E Gordon, Chen Wang, Matthew B Cooke, Brendan F Kohrn, Scott R Kennedy, Olivier Lichtarge, Shannon E Ronca, Christophe Herman

Abstract readPreprint
In one paragraph

Article in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Catherine C BradleyDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.
Alasdair J E GordonDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.
Chen WangDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.
Matthew B CookeDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.ORCID 0000-0003-0964-2715
Brendan F KohrnDepartment of Laboratory Medicine and Pathology, University of Washington; Seattle, WA 98195, USA.ORCID 0000-0001-9948-2131
Scott R KennedyDepartment of Laboratory Medicine and Pathology, University of Washington; Seattle, WA 98195, USA.ORCID 0000-0002-4444-1145
Olivier LichtargeDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.
Shannon E RoncaFeigin Biosafety Level 3 Facility, Texas Children's Hospital; Houston, Texas 77030, USA.
Christophe HermanDepartment of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas 77030, USA.ORCID 0000-0001-8954-7907

Funding

A Synthetic Platform for Non-Antibiotic Eradication of Bacterial InfectionsDP1AI152073 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI HERMAN, CHRISTOPHE · 2019 to 2023
$5.6M
A Knowledge Map to Find Alzheimer's Disease DrugsR01AG061105 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LICHTARGE, OLIVIER · 2018 to 2022
$4.6M
Molecular Noise, Transcription Errors and Heritable Phenotypic ChangeR01GM088653 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI HERMAN, CHRISTOPHE · 2010 to 2019
$3.1M
Massively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial IndexingR21HG011229 · NHGRI · UNIVERSITY OF WASHINGTON · PI KENNEDY, SCOTT ROBERT, SEELIG, GEORG · 2020 to 2020
$622k
Exploiting Urine Derived DNA for the Assessment of Bladder Cancer using High Accuracy SequencingR21CA259780 · NCI · UNIVERSITY OF WASHINGTON · PI KENNEDY, SCOTT ROBERT · 2021 to 2022
$395k
NCI NIH HHS R21 CA259780NHGRI NIH HHS R21 HG011229NIAID NIH HHS DP1 AI152073NIA NIH HHS R01 AG061105NIGMS NIH HHS R01 GM088653
6 · The paper itself

Abstract

Both the SARS-CoV-2 virus and its mRNA vaccines depend on RNA polymerases (RNAP)

Identifiers

PMID35677076
PMCPMC9176646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.