Evidence map›Paper›PMID 35676734›Full record

ArticleAlzheimer's research & therapy2022

Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography.

Luka Rejc, Vanessa Gómez-Vallejo, Ana Joya, Gemma Arsequell, Ander Egimendia, Pilar Castellnou, Xabier Ríos-Anglada, Unai Cossío, Zuriñe Baz, Leyre Iglesias and 4 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. NADCell death & disease · 2024
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  12. Abnormal [Synapse (New York, N.Y.) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Luka RejcCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain. rejc.luka87@gmail.com.
Vanessa Gómez-VallejoCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Ana JoyaCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Gemma ArsequellInstitut de Química Avançada de Catalunya (IQAC), Spanish National Research Council (IQAC-CSIC), 08034, Barcelona, Spain.
Ander EgimendiaCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Pilar CastellnouCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Xabier Ríos-AngladaCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Unai CossíoCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Zuriñe BazCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Leyre IglesiasLaboratory of Neuroimaging and biomarkers of inflammation, UPV/EHU, Sede building B. Sarriena, Achucarro Basque Center for Neuroscience, 48940, Science ParkLeioa, Spain.
Estibaliz Capetillo-ZarateFaculty of Medicine and Nursery, University of the Basque Country UPV/EHU, Achucarro Basque Center for Neuroscience and CIBERNED, Barrio Sarriena S/N, 48940, Leioa, Spain.
Pedro Ramos-CabrerCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain.
Abraham MartinLaboratory of Neuroimaging and biomarkers of inflammation, UPV/EHU, Sede building B. Sarriena, Achucarro Basque Center for Neuroscience, 48940, Science ParkLeioa, Spain.
Jordi LlopCIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramon 182, 20014, San Sebastian, Spain. jllop@cicbiomagune.es.
CIC biomaGUNE · ESAchucarro Basque Center for Neuroscience · ESBiomedical Research Networking Center on Neurodegenerative Diseases · ESIkerbasque · ESInstitute of Advanced Chemistry of Catalonia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundValidation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation biomarkers, such as translocator protein (TSPO) and cystine/glutamine antiporter system (x

methodsExpression of TSPO and x

resultsPET studies showed a significant increase in the uptake of [

conclusionsTSPO and x

Indexed as

Alzheimer DiseaseAmyloidosisAnimalsDisease Models, AnimalDisease ProgressionHumansMiceNeuroinflammatory DiseasesOxidative StressPositron-Emission TomographyReceptors, GABAReceptors, GABATSPO protein, humanAlzheimer diseaseOxidative stressPositron emission tomographyTSPO

Identifiers

PMID35676734
PMCPMC9178858
OpenAlexW4281770466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.