Evidence map›Paper›PMID 35676712›Full record

ReviewJournal of medical case reports2022

Acute benign pleural effusion, a rare presentation of hepatitis A virus: a case report and review of the literature.

Jihad Samer Zalloum, Tareq Z Alzughayyar, Fawzy M Abunejma, Ibba Mayadma, Layan Ziad Tomeh, Karim Jamal Abulaila, Asil Husam Yagmour, Khalid Jamal Faris, Mohammed A S Aramin, Mo'min Ra'id Mesk and 6 more

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Current perspectives of viral hepatitis.World journal of gastroenterology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jihad Samer ZalloumFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine. Jihad.s.zalloum@gmail.com.ORCID http://orcid.org/0000-0002-1309-0880
Tareq Z AlzughayyarFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Fawzy M AbunejmaAl-Ahli Hospital, Hebron, Palestine.
Ibba MayadmaFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Layan Ziad TomehFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Karim Jamal AbulailaFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Asil Husam YagmourFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Khalid Jamal FarisFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Mohammed A S AraminFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Mo'min Ra'id MeskFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Asala Khalil HasaniFaculty of Medicine, Palestine Polytechnic University, Hebron, State of Palestine.
Balqis Mustafa ShawerFaculty of Medicine, Palestine Polytechnic University, Hebron, State of Palestine.
Rawand Hisham TitiFaculty of Medicine, Palestine Polytechnic University, Hebron, State of Palestine.
Ayat A Z AljubaFaculty of Medicine, Palestine Polytechnic University, Hebron, State of Palestine.
Hussam I A AlzeerelhouseiniFaculty of Medicine, Al-Quds University, Main Campus, P.O. Box 89, Abu Dis, Palestine.
Yousef I M ZatariFaculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Al-Quds University · PSPalestine Polytechnic University · PSAl-Ahli Hospital · QAAn-Najah National University · PS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatitis A virus infections are mostly asymptomatic or mildly symptomatic, and generally this disease has a benign course and resolves spontaneously. However, intrahepatic and rarer extrahepatic manifestations can complicate typical cases of acute hepatitis. Pleural effusion is an extremely rare extrahepatic entity with 20 cases reported in literature. CASE PRESENTATION: We report herein a recent case of both pleural effusion and ascites accompanying hepatitis A infection in a 5-year-old middle eastern child, diagnosed using serological testing and imaging studies, who was treated with supportive management with full resolution after 2 weeks. In addition, we review available literature regarding hepatitis A virus associated with pleural effusion using PubMed and summarize all reported cases in a comprehensive table.

resultsLiterature contains 20 reported cases of serology-confirmed hepatitis A virus presenting with pleural effusion, most in the pediatric population with average age at presentation of 9 years 8 months. The majority of reported patients had right-sided pleural effusion (50%) or bilateral effusion (45%), while only 5% presented with pleural effusion on the left side. Hepatomegaly and ascites occurred concurrently in 80% and 70% respectively. Supportive treatment without invasive procedures (except one chylothorax case) yielded complete recovery in 95% of cases, while only one case progressed to fulminant liver failure followed by death.

conclusionAcute hepatitis A virus rarely presents with pleural effusion, usually following a benign course with spontaneous resolution in most patients. Pleural effusion does not change the prognosis or require any invasive treatment. Thus, further invasive procedures are not recommended and would only complicate this self-resolving benign condition.

Indexed as

ChylothoraxHepatitis AHepatitis A virusPleural EffusionAscitesChildChild, PreschoolHumansAcute hepatitisAcute hepatitis A virusAscitesConservative managementHAV associated with self-limited pleural effusionPleural effusionUnusual manifestation

Identifiers

PMID35676712
PMCPMC9178849
OpenAlexW4281760892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.