Observational studyWorld journal of surgical oncology2022
Metaplastic carcinoma of the breast with squamous differentiation: prognostic factors and multidisciplinary treatment.
Observational study in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Imaging and Clinicopathological Features of Squamous Cell Metaplastic Breast Carcinoma: A 22-Case Retrospective Study.Journal of clinical medicine · 2026Article
- A Chain-of-thought Reasoning Breast Ultrasound Dataset Covering All Histopathology Categories.Scientific data · 2026Article
- Primary squamous cell carcinoma of the breast: a case report.Discover oncology · 2024Article
- Metaplastic Breast Cancer with Squamous Differentiation: Beyond the Recognized Statistics.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024Review
- Cavitary lung metastases of mixed metaplastic breast cancer mimicking aspergilloma.Thoracic cancer · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to analyze the characteristics of patients diagnosed with metaplastic carcinoma of the breast with squamous differentiation and to identify the particular clinical and histological characteristics that need to be taken into account in this type of tumors. CASE PRESENTATION: Retrospective observational study of two patients managed at our hospital between 2014 and 2020 (15 months mean follow-up), plus all cases published in the last 7 years (8 patients). Thus, a total of 10 cases were analyzed, all with less than 2 years mean global survival. Studied variables were: age, medical background, tumor size, axillary involvement, radiological characteristics, surgical approach, complementary treatments, histologic characteristics, and progression of the disease. In 50% of cases, the disease appeared as a palpable mass of rapid growth, associated with axillary infiltration; 80% of the tumors were triple negative; 30% of them progressed to distant metastatic disease in 30%.
conclusionsThis unusual carcinoma requires a complex multidisciplinary treatment. Its prognosis is unfavorable due to its high local aggressiveness, with rapid progression and appearance of metastatic disease. The predominance of different histological components may determine the response to medical treatments.
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Registered trials
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