ArticleAnnals of surgical oncology2022
Predictors of Sentinel Lymph Node Metastasis in Patients with Thin Melanoma: An International Multi-institutional Collaboration.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Towards Accurate Breslow Measurements: Mitigating Issues in Histopathological Imaging.Entropy (Basel, Switzerland) · 2026Article
- Association of primary lesion surgery and surgical modality with overall survival in patients with stage IV cutaneous melanoma: a population-based study.Translational cancer research · 2026Article
- Review
- CDCA3 is a prognostic biomarker for cutaneous melanoma and is connected with immune infiltration.Frontiers in oncology · 2022Article
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Authors and funding
13 authors.
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Abstract
backgroundConsideration of sentinel lymph node biopsy (SLNB) is recommended for patients with T1b melanomas and T1a melanomas with high-risk features; however, the proportion of patients with actionable results is low. We aimed to identify factors predicting SLNB positivity in T1 melanomas by examining a multi-institutional international population.
methodsData were extracted on patients with T1 cutaneous melanoma who underwent SLNB between 2005 and 2018 at five tertiary centers in Europe and Canada. Univariable and multivariable logistic regression analyses were performed to identify predictors of SLNB positivity.
resultsOverall, 676 patients were analyzed. Most patients had one or more high-risk features: Breslow thickness 0.8-1 mm in 78.1% of patients, ulceration in 8.3%, mitotic rate > 1/mm
conclusionsOur international multi-institutional data confirm that Breslow thickness and mitotic rate independently predict SLNB positivity in patients with T1 melanoma. Even within this highly selected population, the number needed to diagnose is 13:1 (7.8%), indicating that more work is required to identify additional predictors of sentinel node positivity.
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