ArticleNature2022
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
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Who cites it
70 citing papers in PubMed, 116 citations in OpenAlex.
- Targeting ROAM1 with UDP-GlcNAc nanosheets selective activates lysosomal AMPK to resolve metabolic dysfunction-associated steatotic liver disease.Bioactive materials · 2026Article
- Acute exercise-induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice.Experimental physiology · 2026Article
- Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk.Biochemical Society transactions · 2026Review
- Lipid Class Prediction from MS1 Data using Gaussian Graphical Models.Analytical chemistry · 2026Article
- FAHFAs are detected in postprandial chylomicron and VLDL fractions and can be released from TG estolides by LPL in vitro.Journal of lipid research · 2026Article
- Total Flavonoids ofNutrients · 2026Article
- Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ATGL-catalyzed biosynthesis mediates the upregulation of fatty acid hydroxy fatty acids (FAHFA) levels in white adipose tissue with fasting.The Journal of biological chemistry · 2026Article
- Patatin-domain-containing (phospho)lipases under control: Mammalian co-regulators and pathogenic activation mechanisms.FEBS open bio · 2026Review
- Comparative analysis of bioactivities of leaf extracts from wild plant speciesFrontiers in pharmacology · 2026Article
- DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrative analysis of genome and transcriptome reveals a novel regulator for pork intramuscular fat content.Genetics, selection, evolution : GSE · 2025Article
- The effects of saturated fatty acid supplements on plasma and milk concentration of fatty acid esters of hydroxy fatty acids in dairy cows.JDS communications · 2025Article
- DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains.bioRxiv : the preprint server for biology · 2025Article
- Exercise-regulated lipolysis: Its role and mechanism in health and diseases.Journal of advanced research · 2025Review
- Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome.Diabetology & metabolic syndrome · 2025Review
- Nitrogen limitation causes a seismic shift in redox state and phosphorylation of proteins implicated in carbon flux and lipidome remodeling in Rhodotorula toruloides.Biotechnology for biofuels and bioproducts · 2025Article
- The balancing act between lipid droplets and lysosomes for membrane functionality in age-related neurodegeneration and inflammation.Progress in lipid research · 2025Review
- Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.Nature metabolism · 2025Article
- The measurement, regulation and biological activity of FAHFAs.Nature chemical biology · 2025Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Rucha PatelDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Anna SantoroDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2276-5659
Peter HoferInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Dan TanClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.
Monika ObererInstitute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0003-2525-9513
Andrew T NelsonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, CA, USA.
Srihari KonduriSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-1618-3932
Dionicio SiegelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, CA, USA.
Rudolf ZechnerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Alan SaghatelianClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0427-563X
Barbara B KahnDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. bkahn@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-4027-0000
Beth Israel Deaconess Medical Center · USUniversity of California San Diego · USUniversity of Graz · ATSalk Institute for Biological Studies · US
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MTraining Program in Cardiovascular ResearchT32HL007374 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MITTLEMAN, MURRAY A · 1985 to 2019
$7.9MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MRegulation of the biosynthesis of a novel class of anti-diabetic lipidsR01DK106210 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B., SAGHATELIAN, ALAN · 2016 to 2024
$6.6MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4MGLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETESR01DK043051 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B. · 1992 to 2020
$4.4MMechanisms for the regulation of novel lipids in vivoK01DK128075 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SANTORO, ANNA · 2021 to 2025
$755kA Hybrid Quadrupole-Orbitrap LC/MSS10OD021815 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SAGHATELIAN, ALAN · 2016 to 2016
$580kGlucose Transporter Regulation in Obesity and DiabetesR56DK043051 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAHN, BARBARA B. · 2022 to 2022
$173kSAR and Biosynthetic Origins of PAHSAs, a Novel Family of Anti-Diabetic LipidsF30DK112622 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI NELSON, ANDREW T · 2016 to 2019
$138kNCI NIH HHS P30 CA014195NHLBI NIH HHS T32 HL007374NIDDK NIH HHS F30 DK112622NIDDK NIH HHS K01 DK128075NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK043051NIDDK NIH HHS R01 DK106210NIDDK NIH HHS R56 DK043051NIDDK NIH HHS T32 DK007516NIH HHS S10 OD021815
Abstract
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals
Indexed as
AcyltransferasesEstersFatty AcidsHydroxy AcidsAdipose TissueAnimalsDiglyceridesEsterificationHumansInsulin ResistanceLipaseMiceTriglyceridesAcyltransferasesDiglyceridesEstersFatty AcidsHydroxy AcidsLipasePNPLA2 protein, humanPNPLA2 protein, mouseTriglycerides
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