ArticleNature2022
Targeting thalamic circuits rescues motor and mood deficits in PD mice.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Gray matter structural and functional brain abnormalities in Parkinson's disease: a meta-analysis of VBM and ALFF data.Journal of neurology · 2025Pooled it
- Bright light therapy in Parkinson's disease: a pilot study on visual pathway improvements.BMC psychiatry · 2025Trial
- Neurotoxicity, α-synuclein pathology, and mitochondrial dysfunction: A comparative study of different mouse models of Parkinson's disease.Neural regeneration research · 2026Article
- Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study.MedComm · 2026Article
- Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia.The Journal of clinical investigation · 2026Article
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Neurostructural Correlates and Impulsive Mechanisms of Exercise Dependence in Middle-Aged and Elderly Adults: Evidence from Gray Matter and Structural Covariance Networks.Brain topography · 2026Article
- The complement C3-microglial axis in depression of Parkinson's disease: from mechanism to therapeutic intervention.EBioMedicine · 2026Article
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Bidirectional Hopf bifurcation control of narrowband gamma oscillations in Parkinson's disease by the corticothalamic system via non-canonical pathways.Journal of computational neuroscience · 2026Article
- Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.Brain communications · 2026Article
- The role of challenging exercise in improving behavioral dysfunction in a mouse model of Parkinson's disease.Frontiers in behavioral neuroscience · 2026Article
- Causal Effects Between Neurodegenerative Diseases, Metabolites, and Brain Volume.Current Alzheimer research · 2026Article
- Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson's Disease.PLoS biology · 2025Article
- Spatiotemporal Brain Transcriptomics Reveal Risk Gene Hot-Spots in Major Neuropsychiatric Disorders.Research square · 2025Article
- Distinct roles of two thalamostriatal systems in visually triggered decision-making in common marmosets.iScience · 2025Article
- Key Connectomes and Synaptic-Compartment-Specific Risk Genes Drive Pathological α-Synuclein Spreading.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Whole Brain Monosynaptic Input of Distinct Neurons in the Globus Pallidus Externa.CNS neuroscience & therapeutics · 2025Article
- Abnormal iron metabolism in the zona incerta in Parkinson's disease mice.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Ying Zhang *McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. zhangyin@mit.edu.ORCID http://orcid.org/0000-0001-6675-3273
Dheeraj S Roy *Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. droy@broadinstitute.org.ORCID http://orcid.org/0000-0002-5218-1216
Yi ZhuCenter for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yefei ChenShenzhen Key Laboratory for Molecular Biology of Neural Development, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Tomomi AidaMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yuanyuan HouMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chenjie ShenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nicholas E LeaMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Margaret E SchroederMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Keith M SkaggsMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Heather A SullivanMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kyle B FischerSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA, USA.
Edward M CallawaySystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6366-5267
Ian R WickershamMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0389-5324
Ji DaiShenzhen Key Laboratory for Molecular Biology of Neural Development, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-2917-2941
Xiao-Ming LiCenter for Neuroscience and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-8617-1702
Zhonghua LuShenzhen Key Laboratory for Molecular Biology of Neural Development, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Guoping FengMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. fengg@mit.edu.ORCID http://orcid.org/0000-0002-8021-277X
McGovern Institute for Brain Research · USChinese Academy of Sciences · CNBroad Institute · USSalk Institute for Biological Studies · USSecond Affiliated Hospital of Zhejiang University · CN
Funding
Neurosciences Graduate Training ProgramT32NS061847 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Brenda L Bloodgood · 2008 to 2026
$7.7MA Molecular and Cellular Atlas of the Marmoset BrainU01MH114819 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2017 to 2021
$6.9MModeling Histone Demethylase Function in NeurogenesisR21NS125121 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BHATTACHARYYA, ANITA, SRIDHARAN, RUPA · 2022 to 2022
$414kDetermining the Role of Distinct Parafascicular Thalamic Circuits in Motor Behaviors Relevant to Parkinson’s DiseaseK99NS125131 · NINDS · BROAD INSTITUTE, INC. · PI ROY, DHEERAJ · 2022 to 2023
$217kNIMH NIH HHS U01 MH114819NINDS NIH HHS K99 NS125131NINDS NIH HHS R21 NS125121NINDS NIH HHS T32 NS061847
Abstract
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with Parkinson's disease (PD), patients also experience motor learning impairments and non-motor symptoms such as depression
Indexed as
AffectMotor SkillsNeural PathwaysParkinson DiseaseThalamusAnimalsDisease Models, AnimalLearningLocomotionLong-Term PotentiationMiceNeuronsNucleus AccumbensOptogeneticsPutamenReceptors, NicotinicReceptors, Nicotinic
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.