ArticleNature2022
Cohesin-mediated loop anchors confine the locations of human replication origins.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
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Who cites it
85 citing papers in PubMed, 122 citations in OpenAlex.
- Folding a broken genome: the versatile roles of cohesin in genome maintenance.Nature reviews. Genetics · 2026Review
- Article
- Systematic evaluation of the heterogeneity of topologically associating domain boundaries in a large genomic context in humans.NAR genomics and bioinformatics · 2026Article
- Cohesin prevents local mixing of condensed euchromatic domains in living human cells.Nature genetics · 2026Article
- Integrating heterogeneity into topologically associating domain boundary prediction in large genomic context in human.NAR genomics and bioinformatics · 2026Article
- Direct visualization of MCM helicase activation and replisome coupling in situ.bioRxiv : the preprint server for biology · 2026Article
- Article
- Re-establishment of TAD boundary organization during DNA replication.bioRxiv : the preprint server for biology · 2026Article
- Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.Medical review (2021) · 2026Review
- Replication origin flexibility: a tool to mitigate the hazards of excess replication.Trends in genetics : TIG · 2026Review
- Cohesin prevents local mixing of condensed euchromatic domains in living human cells.bioRxiv : the preprint server for biology · 2026Article
- Conserved 3D genome reorganization during DNA repair.Life science alliance · 2026Review
- Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription.Nature structural & molecular biology · 2026Article
- DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains.Nature communications · 2026Article
- Cohesin mutations and chromatin changes in cancer.International journal of cancer · 2026Review
- OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells.Nature communications · 2026Article
- Article
- Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes.Genome biology · 2025Article
- Cohesin drives chromatin scanning during the RAD51-mediated homology search.Science (New York, N.Y.) · 2025Article
- Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels.Nature communications · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 10 institutions in 4 countries.
Daniel J Emerson *Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Peiyao A Zhao *Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Ashley L Cook *Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6789-5732
R Jordan BarnettDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Kyle N KleinDepartment of Biological Science, Florida State University, Tallahassee, FL, USA.
Dalila SaulebekovaInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France.
Chunmin GeDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Linda ZhouDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Zoltan SimandiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Miriam K MinskDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Katelyn R TitusDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Weitao WangInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France.
Wanfeng GongDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Di ZhangChildren's Hospital of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9007-4665
Liyan YangUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Sergey V VenevUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-1507-7460
Johan H GibcusUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-0851-7560
Hongbo YangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Takayo SasakiSan Diego Biomedical Research Institute, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-7609-9316
Masato T KanemakiDepartment of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Japan.ORCID http://orcid.org/0000-0002-7657-1649
Feng YueDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID http://orcid.org/0000-0002-7954-5462
Job DekkerUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-5631-0698
Chun-Long ChenInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-4795-0295
David M GilbertDepartment of Biological Science, Florida State University, Tallahassee, FL, USA.ORCID http://orcid.org/0000-0001-8087-9737
Jennifer E Phillips-CreminsDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. jcremins@seas.upenn.edu.ORCID http://orcid.org/0000-0002-4702-0450
University of Pennsylvania · USCentre National de la Recherche Scientifique · FRFlorida State University · USUniversity of Massachusetts Chan Medical School · USNorthwestern University · USChildren's Hospital of Philadelphia · USHoward Hughes Medical Institute · USNational Institute of Genetics · JPNew York Stem Cell Foundation · USSan Diego Biomedical Research Institute · US
Funding
Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB · 2015 to 2019
$14.9MCenter for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8MMapping Technology DevelopmentU54DK107965 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GILBERT, DAVID M · 2015 to 2019
$8.6MGenome Plasticity during ES Cell Differentiation to Neural LineagesR01GM083337 · NIGMS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI David M Gilbert · 2007 to 2026
$6.1MFrom 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memoryDP1MH129957 · NIMH · WASHINGTON UNIVERSITY · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2021 to 2025
$5.7MEngineering and Imaging 3D genome structure-function dynamics across time scalesU01DK127405 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2020 to 2024
$5.7MEngineering and visualizing genome folding at high spatiotemporal resolutionU01HL129998 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2015 to 2019
$4.2MSingle-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingU01DA052715 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN, JOYCE, ERIC F. · 2020 to 2024
$3.1MConnecting 3D genome misfolding to transcriptional silencing in fragile X syndromeR01MH120269 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2019 to 2024
$3.1MMapping the 3D architecture of native human replisomesR01HG010658 · NHGRI · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI GILBERT, DAVID M · 2019 to 2022
$2.1MConnecting 3D genome misfolding to transcriptional silencing in fragile X syndromeR37MH120269 · NIMH · WASHINGTON UNIVERSITY · PI Jennifer Elizabeth Phillips-Cremins · 2025 to 2026
$1.0MHoward Hughes Medical InstituteNHGRI NIH HHS R01 HG010658NHGRI NIH HHS UM1 HG011536NHLBI NIH HHS U01 HL129998NIDA NIH HHS U01 DA052715NIDDK NIH HHS U01 DK127405NIDDK NIH HHS U54 DK107965NIDDK NIH HHS U54 DK107980NIGMS NIH HHS R01 GM083337NIMH NIH HHS DP1 MH129957NIMH NIH HHS R01 MH120269NIMH NIH HHS R37 MH120269
Abstract
DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability
Indexed as
Cell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneReplication OriginCohesinsDNA ReplicationHumansS PhaseCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.