ArticleNature2022
Graph pangenome captures missing heritability and empowers tomato breeding.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 296 papers.
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296citing papers in PubMed
40.6field-weighted citation impact, top 1% of its field
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296 citing papers in PubMed, 488 citations in OpenAlex.
- Unlocking the future of crop improvement with crop wild relatives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Uncovering structural variation in conifer gigagenomes: evolutionary insights and technical challenges.Molecular biology and evolution · 2026Article
- European ash pangenome reveals widespread structural variation and genetic basis of low ash dieback susceptibility.Nature communications · 2026Article
- Multi-variant GWAS and genomic prediction dissect the genetic architecture underlying tomato fruit weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Pangenomic analyses in the cultivated grapevine confirm high genomic collinearity and extensive dispensable gene content likely involved in adaptation.G3 (Bethesda, Md.) · 2026Article
- Graph-based pangenomics reveals the genetic basis of agronomic traits in tomato fruits.Horticulture research · 2026Article
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- A pangenome framework uncovers the role of deletions in repeated evolution of cave-derived traits.Genome research · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Pan-Genomic Dissection of GH1 β-Glucosidases inPlants (Basel, Switzerland) · 2026Article
- Integrating deep learning and pangenomics to recover missing heritability from wild structural variations.BMC genomics · 2026Review
- Empowering Plant Biotechnology Research: Super-Pangenomes as a Novel Arsenal for Crop Breeding and Improvement.Molecular biotechnology · 2026Review
- Structural Variation and Its Roles in Plant Genomes.Plants (Basel, Switzerland) · 2026Review
- A spatiotemporal atlas of giant-cell formation during Meloidogyne incognita infection in tomato roots.Molecular horticulture · 2026Article
- A transposable element-derived regulatory variation inHorticulture research · 2026Article
- New biologically relevant resistance to bacterial wilt in heat-stressed tomato revealed by two-reference Genome Wide Association.PLoS genetics · 2026Article
- Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber.Nature genetics · 2026Article
- A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding.Nature genetics · 2026Article
- Genomic structural variation rescues a classic biological invader from a population bottleneck.Science advances · 2026Article
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236 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 7 institutions in 5 countries.
Yao Zhou *Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0001-9791-7664
Zhiyang Zhang *Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-9466-9439
Zhigui Bao *Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-3601-460X
Hongbo LiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-1579-4600
Yaqing LyuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Yanjun ZanShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Yaoyao WuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Lin ChengShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Yuhan FangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-1604-1988
Kun WuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Jinzhe ZhangKey Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture, Sino-Dutch Joint Laboratory of Horticultural Genomics, and Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-3127-4488
Hongjun LyuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Tao LinState Key Laboratory of Agrobiotechnology, College of Horticulture, China Agricultural University, Beijing, China.
Qiang GaoBoke Biotech, Wuxi, China.ORCID http://orcid.org/0000-0002-9323-1101
Surya SahaBoyce Thompson Institute, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-1160-1413
Lukas MuellerBoyce Thompson Institute, Cornell University, Ithaca, NY, USA.
Zhangjun FeiBoyce Thompson Institute, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-9684-1450
Thomas StädlerInstitute of Integrative Biology & Zurich, Basel Plant Science Center, ETH Zurich, Zurich, Switzerland.
Shizhong XuDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Zhiwu ZhangDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, USA.ORCID http://orcid.org/0000-0002-5784-9684
Doug SpeedQuantitative Genetics and Genomics (QGG), Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0096-9765
Sanwen HuangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. huangsanwen@caas.cn.ORCID http://orcid.org/0000-0002-8547-5309
Agricultural Genomics Institute at Shenzhen · CNCornell University · USAarhus University · DKChina Agricultural University · CNETH Zurich · CHInstitute of Vegetables and Flowers · CNUniversity of California, Riverside · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits
Indexed as
Genetic VariationGenome, PlantGenome-Wide Association StudyPlant BreedingSolanum lycopersicumAllelesCrops, AgriculturalLinkage Disequilibrium
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