Evidence map›Paper›PMID 35676292›Full record

ArticleScientific reports2022

Substrate-dependent modulation of the leukotriene A

Kyung Hyeon Lee, Nadia Fazal Ali, Soo Hyeon Lee, Zhimin Zhang, Marie Burdick, Zachary J Beaulac, Greg Petruncio, Linxia Li, Jiangdong Xiang, Ezra M Chung and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Characterization ofJournal of medical microbiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Kyung Hyeon LeeDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Nadia Fazal AliDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Soo Hyeon LeeWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA.
Zhimin ZhangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, PO Box 800546, Charlottesville, VA, 22908, USA.
Marie BurdickDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, PO Box 800546, Charlottesville, VA, 22908, USA.
Zachary J BeaulacDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Greg PetruncioDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Linxia LiDepartment of Obstetrics and Gynecology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Shanghai, 200137, China.
Jiangdong XiangDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Ezra M ChungSTCube Pharmaceutical, Inc., 401 Professional Dr, Gaithersburg, MD, 20879, USA.
Kenneth W ForemanDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.
Schroeder M NobleWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA. schroeder.m.noble.civ@mail.mil.
Yun M ShimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, PO Box 800546, Charlottesville, VA, 22908, USA. yss6n@virginia.edu.
Mikell PaigeDepartment of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA. mpaige3@gmu.edu.
George Mason University · USUniversity of Virginia · USWalter Reed Army Institute of Research · USSeventh People's Hospital of Shanghai · CNShanghai First People's Hospital · CNSTCube (United States) · US

Funding

Hyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9M
Discovery of New Anti-Inflammatory Agents to Treat COPDR01HL132287 · NHLBI · GEORGE MASON UNIVERSITY · PI NOBLE, SCHROEDER M, PAIGE, MIKELL · 2016 to 2019
$2.4M
Biology of Leukotrienes in the Pathogenesis of EmphysemaK08HL091127 · NHLBI · UNIVERSITY OF VIRGINIA · PI SHIM, YUN MICHAEL · 2008 to 2012
$643k
NHLBI NIH HHS K08 HL091127NHLBI NIH HHS R01 HL132177NHLBI NIH HHS R01 HL132287NIH HHS R01HL132287
6 · The paper itself

Abstract

The aminopeptidase activity (AP) of the leukotriene A

Indexed as

Epoxide HydrolasesPneumoniaAnimalsDisease Models, AnimalLigandsMiceEpoxide Hydrolasesleukotriene A4 hydrolaseLigands

Identifiers

PMID35676292
PMCPMC9177663
OpenAlexW4282923436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.