ArticleNature communications2022
Hippocampal representations switch from errors to predictions during acquisition of predictive associations.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Unsupervised nonmotor learning in the human cerebellum.bioRxiv : the preprint server for biology · 2026Article
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Music enhances associative generalization: Evidence from a memory integration task.Memory & cognition · 2026Article
- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- Article
- Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- Rapid computation of high-level visual surprise.iScience · 2025Article
- Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.Science advances · 2025Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.bioRxiv : the preprint server for biology · 2025Article
- Article
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Shaping the Space: A Role for the Hippocampus in Mental Imagery Formation.Vision (Basel, Switzerland) · 2025Review
- Memory-based predictions prime perceptual judgments across head turns in immersive, real-world scenes.Current biology : CB · 2025Article
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- The brain hierarchically represents the past and future during multistep anticipation.Nature communications · 2024Article
- The brain hierarchically represents the past and future during multistep anticipation.bioRxiv : the preprint server for biology · 2024Article
- Prediction error processing and sharpening of expected information across the face-processing hierarchy.Nature communications · 2024Article
- Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors.Journal of affective disorders reports · 2024Article
- Insights into hippocampal perfusion using high-resolution, multi-modal 7T MRI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We constantly exploit the statistical regularities in our environment to help guide our perception. The hippocampus has been suggested to play a pivotal role in both learning environmental statistics, as well as exploiting them to generate perceptual predictions. However, it is unclear how the hippocampus balances encoding new predictive associations with the retrieval of existing ones. Here, we present the results of two high resolution human fMRI studies (N = 24 for both experiments) directly investigating this. Participants were exposed to auditory cues that predicted the identity of an upcoming visual shape (with 75% validity). Using multivoxel decoding analysis, we find that the hippocampus initially preferentially represents unexpected shapes (i.e., those that violate the cue regularities), but later switches to representing the cue-predicted shape regardless of which was actually presented. These findings demonstrate that the hippocampus is involved both acquiring and exploiting predictive associations, and is dominated by either errors or predictions depending on whether learning is ongoing or complete.
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