Evidence map›Paper›PMID 35676253›Full record

ArticleNature communications2022

Paramagnetic encoding of molecules.

Jan Kretschmer, Tomáš David, Martin Dračínský, Ondřej Socha, Daniel Jirak, Martin Vít, Radek Jurok, Martin Kuchař, Ivana Císařová, Miloslav Polasek

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Bypassing Heteronuclear MRI: Metal-Free Organosilicon Nanotracers for Background-Free HotspotAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Synthesis ofBiomacromolecules · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jan KretschmerInstitute of Organic Chemistry and Biochemistry of the CAS, Flemingovo náměstí 542/2, 160 00, Prague 6, Czech Republic.
Tomáš DavidInstitute of Organic Chemistry and Biochemistry of the CAS, Flemingovo náměstí 542/2, 160 00, Prague 6, Czech Republic.ORCID 0000-0003-1146-9448
Martin DračínskýInstitute of Organic Chemistry and Biochemistry of the CAS, Flemingovo náměstí 542/2, 160 00, Prague 6, Czech Republic.ORCID 0000-0002-4495-0070
Ondřej SochaInstitute of Organic Chemistry and Biochemistry of the CAS, Flemingovo náměstí 542/2, 160 00, Prague 6, Czech Republic.ORCID 0000-0002-7218-9119
Daniel JirakMR Unit, Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21, Prague 4, Czech Republic.ORCID 0000-0001-6834-3462
Martin VítMR Unit, Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21, Prague 4, Czech Republic.ORCID 0000-0002-4296-9368
Radek JurokForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
Martin KuchařForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.ORCID 0000-0002-7616-6352
Ivana CísařováDepartment of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 128 43, Prague 2, Czech Republic.ORCID 0000-0002-9612-9831
Miloslav PolasekInstitute of Organic Chemistry and Biochemistry of the CAS, Flemingovo náměstí 542/2, 160 00, Prague 6, Czech Republic. miloslav.polasek@uochb.cas.cz.ORCID 0000-0003-1539-907X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contactless digital tags are increasingly penetrating into many areas of human activities. Digitalization of our environment requires an ever growing number of objects to be identified and tracked with machine-readable labels. Molecules offer immense potential to serve for this purpose, but our ability to write, read, and communicate molecular code with current technology remains limited. Here we show that magnetic patterns can be synthetically encoded into stable molecular scaffolds with paramagnetic lanthanide ions to write digital code into molecules and their mixtures. Owing to the directional character of magnetic susceptibility tensors, each sequence of lanthanides built into one molecule produces a unique magnetic outcome. Multiplexing of the encoded molecules provides a high number of codes that grows double-exponentially with the number of available paramagnetic ions. The codes are readable by nuclear magnetic resonance in the radiofrequency (RF) spectrum, analogously to the macroscopic technology of RF identification. A prototype molecular system capable of 16-bit (65,535 codes) encoding is presented. Future optimized systems can conceivably provide 64-bit (~10^19 codes) or higher encoding to cover the labelling needs in drug discovery, anti-counterfeiting and other areas.

Indexed as

Lanthanoid Series ElementsHumansMagnetic Resonance SpectroscopyMagneticsLanthanoid Series Elements

Identifiers

PMID35676253
PMCPMC9177614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.