ArticleNeurology(R) neuroimmunology & neuroinflammation2022
CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke.Genes & diseases · 2025Article
- Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units.Neural regeneration research · 2024Article
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Authors and funding
14 authors at 1 institution in 2 countries.
Kirsten GuseFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Nina HagemannFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Lisa ThieleFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Jana RemlingerFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Anke SalmenFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.ORCID 0000-0002-4751-299X
Robert HoepnerFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Irene KellerFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Patricia MeyerFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Denis GrandgirardFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.ORCID 0000-0002-4151-5196
Stephen L LeibFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.ORCID 0000-0002-1106-6123
Erik VassellaFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Giuseppe LocatelliFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Dirk M HermannFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland.
Andrew ChanFrom the Department of Neurology (K.G., L.T., J.R., A.S., R.H., A.C.), Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Switzerland; Department of Neurology (K.G., L.T.), St. Josef-Hospital, Ruhr-University, Bochum, Germany; Department of Neurology (N.H., D.M.H.), Chair of Vascular Neurology, Dementia and Ageing Research, University of Duisburg-Essen, Germany; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics (I.K.), Department for BioMedical Research (DBMR), Neuroinfection Laboratory (P.M., D.G., S.L.L.), Institute for Infectious Diseases, Institute of Pathology (E.V.), and Theodor Kocher Institute (G.L.), University of Bern, Switzerland. andrew.chan@insel.ch.
SIB Swiss Institute of Bioinformatics · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesExperimental studies indicate shared molecular pathomechanisms in cerebral hypoxia-ischemia and autoimmune neuroinflammation. This has led to clinical studies investigating the effects of immunomodulatory therapies approved in multiple sclerosis on inflammatory damage in stroke. So far, mutual and combined interactions of autoimmune, CNS antigen-specific inflammatory reactions and cerebral ischemia have not been investigated so far.
methodsActive MOG
resultsMice with severe EAE disease showed a substantial reduction in infarct size after tMCAO. Histopathologic analysis showed less infiltration of CD45 DISCUSSION: CNS autoantigen-specific autoimmunity has a protective influence on primary tissue damage after experimental stroke, indicating a very early involvement of CNS antigen-specific, myeloid cell-associated anti-inflammatory immune mechanisms that mitigate ischemic injury in the acute EAE phase.
Indexed as
Encephalomyelitis, Autoimmune, ExperimentalIschemic StrokeStrokeAnimalsInfarctionMaleMiceMice, Inbred C57BLMyeloid CellsNeuroinflammatory Diseases
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