Evidence map›Paper›PMID 35676038›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Pulmonary and Intestinal Involvement in a Patient with Myeloperoxidase-specific Antineutrophil Cytoplasmic Antibody-positive Hermansky-Pudlak Syndrome.

Takatomo Tokito, Noriho Sakamoto, Hiroshi Ishimoto, Daisuke Okuno, Takuto Miyamura, Atsuko Hara, Takashi Kido, Kazuko Yamamoto, Hiroyuki Yamaguchi, Yasushi Obase and 5 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Takatomo TokitoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Noriho SakamotoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Hiroshi IshimotoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Daisuke OkunoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Takuto MiyamuraDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Atsuko HaraDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Takashi KidoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Kazuko YamamotoDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Hiroyuki YamaguchiDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yasushi ObaseDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yuko AkazawaTissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University, Japan.
Ken OkamuraDepartment of Dermatology, Faculty of Medicine, Yamagata University, Japan.
Tamio SuzukiDepartment of Dermatology, Faculty of Medicine, Yamagata University, Japan.
Yuji IshimatsuDepartment of Nursing, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Nagasaki University · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 26-year-old Japanese woman was admitted with a 1-month history of diarrhea, a high fever for a few days, and exacerbation of dyspnea. She was treated with an antifibrotic drug and long-term oxygen therapy for Hermansky-Pudlak syndrome-related pulmonary fibrosis. New ground-glass attenuation appeared on chest computed tomography (CT), and a colon biopsy showed an inflammatory cell accumulation with a high titer of myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (ANCA). Systemic inflammation related to MPO-ANCA titer elevation was suspected. Steroid pulse therapy and intravenous cyclophosphamide improved chest CT findings and diarrhea. Therefore, immunosuppressant treatment should be considered for systemic inflammation related to MPO-ANCA.

Indexed as

Antibodies, Antineutrophil CytoplasmicHermanski-Pudlak SyndromeAdultDiarrheaFemaleHumansInflammationPeroxidaseAntibodies, Antineutrophil CytoplasmicPeroxidasegranulomatous colitisHermansky-Pudlak syndromeMPO-ANCApulmonary fibrosissteroid pulse treatmentvasculitis

Identifiers

PMID35676038
PMCPMC9876727
OpenAlexW4282923552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.