Evidence map›Paper›PMID 35676017›Full record

ArticleBMJ open2022

Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain.

Laura Simons, Massieh Moayedi, Robert C Coghill, Jennifer Stinson, Martin S Angst, Nima Aghaeepour, Brice Gaudilliere, Christopher D King, Marina López-Solà, Marie-Eve Hoeppli and 10 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04285112 (SPRINT), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04285112 active not recruitingnot on this map

SPRINT: Signature for Pain Recovery IN Teens

TypeobservationalSponsorStanford UniversityRan2020 to 2025Enrolled275ConditionsPain, Chronic, Pain, Joint Pain, Musculoskeletal Pain
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Laura SimonsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA lesimons@stanford.edu.ORCID 0000-0002-3395-9483
Massieh MoayediCentre for Multimodal Sensorimotor and Pain Research, University of Toronto Faculty of Dentistry, Toronto, Ontario, Canada.
Robert C CoghillDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Jennifer StinsonDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Brice GaudilliereDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Christopher D KingDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Marina López-SolàSerra Hunter Programme, Department of Medicine, University of Barcelona, Barcelona, Spain.
Marie-Eve HoeppliDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Emma BiggsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Ed GanioDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Sara E WilliamsDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
Kenneth R GoldschneiderPediatric Pain Research Center (PPRC), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Fiona CampbellDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Danielle RuskinDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Elliot J KraneDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Suellen WalkerDevelopmental Neurosciences Department, UCL GOS Institute of Child Health, UCL, London, UK.
Gillian RushDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Marissa HeirichDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Stanford University · USCincinnati Children's Hospital Medical Center · USHospital for Sick Children · CAUniversitat de Barcelona · ESUniversity College London · GBUniversity of Toronto · CA

Funding

SPRINT: Signature for Pain Recovery IN TeensR61NS114926 · NINDS · STANFORD UNIVERSITY · PI SIMONS, LAURA E · 2019 to 2019
$5.4M
NINDS NIH HHS R61 NS114926
6 · The paper itself

Abstract

introductionCurrent treatments for chronic musculoskeletal (MSK) pain are suboptimal. Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. Given that chronic pain is a biopsychosocial process, this study aims to discover and validate a robust prognostic signature that measures across multiple dimensions in the same adolescent patient cohort with a computational analysis pipeline. This will facilitate risk stratification in adolescent patients with chronic MSK pain and more resourceful allocation of patients to costly and potentially burdensome multidisciplinary pain treatment approaches. METHODS AND ANALYSIS: Here we describe a multi-institutional effort to collect, curate and analyse a high dimensional data set including epidemiological, psychometric, quantitative sensory, brain imaging and biological information collected over the course of 12 months. The aim of this effort is to derive a multivariate model with strong prognostic power regarding the clinical course of adolescent MSK pain and function. ETHICS AND DISSEMINATION: The study complies with the National Institutes of Health policy on the use of a single internal review board (sIRB) for multisite research, with Cincinnati Children's Hospital Medical Center Review Board as the reviewing IRB. Stanford's IRB is a relying IRB within the sIRB. As foreign institutions, the University of Toronto and The Hospital for Sick Children (SickKids) are overseen by their respective ethics boards. All participants provide signed informed consent. We are committed to open-access publication, so that patients, clinicians and scientists have access to the study data and the signature(s) derived. After findings are published, we will upload a limited data set for sharing with other investigators on applicable repositories. TRIAL REGISTRATION NUMBER: NCT04285112.

Indexed as

Chronic PainMusculoskeletal PainAdolescentHumansMulticenter Studies as TopicNational Institutes of Health (U.S.)Pain ManagementProspective StudiesUnited StatesIMMUNOLOGYMagnetic resonance imagingPaediatric anaesthesiaPAIN MANAGEMENTSTATISTICS & RESEARCH METHODS

Identifiers

PMID35676017
PMCPMC9185591
OpenAlexW4282924474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.