Evidence map›Paper›PMID 35675936›Full record

SynthesisSaudi medical journal2022

Role of anticoagulation in lowering the mortality in hospitalized covid-19 patients: Meta-analysis of available literature.

Muhammad Aamir Waheed, Khalid Rashid, Tawfik Rajab, Ahmad Rajab, Adnan H Adnan, Harris Fayyaz, Ahmad A Ibad, Rabia Basri, Yahya Khan, Habib I Alhabib and 1 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad Aamir WaheedFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Khalid RashidFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Tawfik RajabFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Ahmad RajabFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Adnan H AdnanFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Harris FayyazFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Ahmad A IbadFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Rabia BasriFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Yahya KhanFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Habib I AlhabibFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.
Abdelnaser ElzoukiFrom the Department of Acute Medicine (Waheed, Rajab, Adnan, Fayyaz) University Hospitals Northampton, Northampton; from the Department of Cardioloogy (Rashid), James Cook University Hospital, Middlesbrough; from the Department of Internal Medicine (Rajab), Calderdale and Huddersfield NHS Foundation Trust, England, United Kingdom; from the Department of Pathology (Ibad), Bannu Medical College, Khyber Medical University, Bannu; from the Department of Medical Education (Khan), Pak International Medical College, Peshawar, Pakistan; from the Department of Anesthesia (Basri), Hamad Medical Corporation; from the Department of Internal Medicine (Elazouki), Hamad Medical Corporation and Weill Cornell Medical College of Qatar, Doha, Qatar; from the Department of Internal Medicine (Alhabib), Dr. Mahasen's Medical Complex, Al Qassim, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitted with covid-19.

methodsA total of 7120 patients were recruited in 11 studies comparing using prophylactic anticoagulants against therapeutic anticoagulants.

resultsOur study showed that using prophylactic anticoagulants was associated with a 42% reduction in mortality compared to therapeutic anticoagulants (OR 0.58 (95% CI:0.676-0.499),

conclusionOur meta-analysis favors using prophylactic anticoagulation in covid-19 patients reduces all-cause mortality in comparison to therapeutic anticoagulation however the impact on mortality when compared with no anticoagulation was not significant.PROSPERO Number: CRD42021257320.

Indexed as

COVID-19 Drug TreatmentThromboembolismVenous ThromboembolismAnticoagulantsBlood CoagulationHumansSARS-CoV-2Anticoagulantsanticoagulationmeta-analysismortality COVID-19SARS-CoV-2

Identifiers

PMID35675936
PMCPMC9389897

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.