ArticleCell reports2022
Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Succinate and lactate produced as conserved biomarkers through chronic and transient substrate-level phosphorylation: from microorganisms to cancer.Journal of bioenergetics and biomembranes · 2026Review
- Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite α-ketoglutarate as a therapeutic strategy.medRxiv : the preprint server for health sciences · 2026Article
- Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma.Scientific reports · 2025Article
- Absolute quantification of TCA cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism.bioRxiv : the preprint server for biology · 2025Article
- An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis.Scientific reports · 2025Article
- Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups.Scientific reports · 2025Article
- RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Acute CClJournal of bioenergetics and biomembranes · 2025Article
- Role of RPE Phagocytosis in the Retina Metabolic Ecosystem.Advances in experimental medicine and biology · 2025Review
- Eye on the horizon: The metabolic landscape of the RPE in aging and disease.Progress in retinal and eye research · 2025Review
- Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration.Bioscience reports · 2024Article
- Remodeling of Hepatic Glucose Metabolism in Response to Early Weaning in Piglets.Animals : an open access journal from MDPI · 2024Article
- "Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation".PloS one · 2024Article
- Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors.Antioxidants (Basel, Switzerland) · 2023Article
- Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa.Cell reports · 2023Article
- Maintaining and Assessing Various Tissue and Cell Types of the Eye Using a Novel Pumpless Fluidics System.Journal of visualized experiments : JoVE · 2023Article
- Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina.bioRxiv : the preprint server for biology · 2023Article
- Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States.Investigative ophthalmology & visual science · 2023Article
- Spatial distribution of metabolites in the retina and its relevance to studies of metabolic retinal disorders.Metabolomics : Official journal of the Metabolomic Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Daniel T HassBiochemistry Department, The University of Washington, Seattle, WA 98195, USA.
Celia M BisbachBiochemistry Department, The University of Washington, Seattle, WA 98195, USA; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA.
Brian M RobbingsBiochemistry Department, The University of Washington, Seattle, WA 98195, USA; Diabetes Institute, The University of Washington, Seattle, WA 98109, USA.
Martin SadilekChemistry Department, The University of Washington, Seattle, WA 98195, USA.
Ian R SweetDiabetes Institute, The University of Washington, Seattle, WA 98109, USA; Division of Metabolism, Endocrinology and Nutrition, The University of Washington, Seattle, WA 98195, USA.
James B HurleyBiochemistry Department, The University of Washington, Seattle, WA 98195, USA; Opthalmology Department, The University of Washington, Seattle, WA 98109, USA. Electronic address: jbhhh@uw.edu.
University of Washington · USPromega (United States) · US
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MROD AND CONE RESPONSE CHARACTERISTICSR01EY006641 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1986 to 2026
$10.2MControl of Photoreceptor MetabolismR01EY017863 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 2007 to 2026
$6.4MVISUAL SCIENCES TRAINING PROGRAMT32EY007031 · NEI · UNIVERSITY OF WASHINGTON · PI Wyeth Daniel Bair, Anitha Pasupathy · 1985 to 2026
$6.1MRespiration in vivo in the Retina and RPER21EY032597 · NEI · UNIVERSITY OF WASHINGTON · PI HURLEY, JAMES BRYANT · 2021 to 2022
$479kUnderstanding the role of cytosolic NADH production in maintaining aerobic glycolysis in the retinaF31EY031165 · NEI · UNIVERSITY OF WASHINGTON · PI BISBACH, CELIA · 2020 to 2021
$76kNEI NIH HHS F31 EY031165NEI NIH HHS R01 EY006641NEI NIH HHS R01 EY017863NEI NIH HHS R21 EY032597NEI NIH HHS T32 EY007031NIDDK NIH HHS P30 DK017047
Abstract
Fumarate can be a surrogate for O
Indexed as
Retinal Pigment EpitheliumSuccinic AcidAdenosine TriphosphateFumaratesRespirationSuccinatesAdenosine TriphosphateFumaratesSuccinatesSuccinic Acidanion transportcell metabolismCP: metabolismenergy metabolismmitochondrial respiratory chainretinal metabolismretinal pigment epitheliumsuccinateuncoupling
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.