Evidence map›Paper›PMID 35675701›Full record

ArticleJournal of pediatric gastroenterology and nutrition2022

Hospitalization With Clostridioides difficile in Pediatric Inflammatory Bowel Disease: a Population-Based Study.

M Ellen Kuenzig, Eric I Benchimol, Charles N Bernstein, Alain Bitton, Matthew W Carroll, Anne M Griffiths, Gilaad G Kaplan, Geoffrey C Nguyen, Anthony R Otley, Therese A Stukel and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Frontiers in pediatrics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 15 institutions in 1 country.

M Ellen KuenzigFrom the SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Eric I BenchimolFrom the SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Charles N Bernsteinthe Univeristy of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Alain Bittonthe McGill University Health Centre, Division of Gastroenterology and Hepatology, Montreal, Québec, Canada.
Matthew W Carrollthe Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Anne M GriffithsFrom the SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Gilaad G Kaplanthe Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Geoffrey C Nguyenthe ICES, Toronto, Ontario, Canada.
Anthony R Otleythe Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Therese A Stukelthe ICES, Toronto, Ontario, Canada.
Trevor J B Dummerthe School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Wael El-Matarythe Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada.
Kevan Jacobsonthe Department of Pediatrics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Jennifer L Jonesthe Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Lisa M Lixthe Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
David R Mackthe Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
Sanjay K Murthythe Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Juan-Nicolás Peña-Sánchezthe School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Laura E Targownikthe Mount Sinai Hospital Centre for Inflammatory Bowel Disease, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stephen G Fungthe ICES, Toronto, Ontario, Canada.
Sarah Spruinthe ICES, Toronto, Ontario, Canada.
Stephanie Cowardthe Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Yunsong Cuithe Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Christopher Filliterthe Lady Davis Institute of Medical Research, Jewish General Hospital, Montreal, Québec, Canada.
Zoann Nugentthe Univeristy of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Shabnaz Siddiqthe ICES, Toronto, Ontario, Canada.
Harminder Singhthe Univeristy of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC)
Institute for Clinical Evaluative Sciences · CAUniversity of Manitoba · CADalhousie University · CAAgricultural Research Institute of Ontario · CAUniversity of British Columbia · CAUniversity of Toronto · CACancerCare Manitoba · CAJewish General Hospital · CAMcGill University Health Centre · CAMount Sinai Hospital · CASouth Health Campus · CAUniversity of Alberta Hospital · CAUniversity of Calgary · CAUniversity of Ottawa · CAUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSeveral studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease (IBD). We conducted a population-based study comparing the risk of hospitalization with CDI in children with and without IBD.

methodsUsing health administrative data and validated algorithms, we identified all children (<16 years) diagnosed with IBD in 5 Canadian provinces, then age and sex matched to 5 children without IBD. Province-specific 5-year incidence rates of hospitalization with CDI were pooled and generalized linear mixed-effects models were used to estimate the crude incidence rate ratio (IRR) comparing (1) children with and without IBD and (2) children with Crohn disease and ulcerative colitis. Hazard ratios (HR) from Cox proportional hazards models adjusting for age, sex, rural/urban household, and income were pooled using fixed-effects models.

resultsThe incidence rate of CDI identified during hospitalization was 49.06 [95% confidence interval (CI), 39.40-61.08] per 10,000 person-years (PY) in 3593 children with IBD compared to 0.39 (95% CI, 0.13-1.21) per 10,000 PY in 16,284 children without IBD (crude IRR, 133.4, 95% CI, 42.1-422.7; adjusted HR, 68.2, 95% CI, 24.4-190.4). CDI was identified less often in children with Crohn disease than ulcerative colitis (crude IRR, 0.51, 95% CI, 0.32-0.82; adjusted HR, 0.69, 95% CI, 0.46-1.05).

conclusionsChildren with IBD have a markedly higher incidence of CDI identified during a hospitalization relative to children without IBD. Consequently, symptomatic children with IBD who are hospitalized should be screened for CDI.

Indexed as

Clostridioides difficileClostridium InfectionsColitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAdultCanadaChildChronic DiseaseClostridioidesHospitalizationHumansRisk Factors

Identifiers

PMID35675701
PMCPMC9278713
OpenAlexW4281704933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.