Evidence map›Paper›PMID 35675613›Full record

ArticleObstetrics and gynecology2022

Utility and Limitations of Human Chorionic Gonadotropin Levels for Remote Follow-up After Medical Management of Early Pregnancy Loss.

Andrea H Roe, Alice Abernathy, Anne N Flynn, Arden McAllister, Nathanael C Koelper, Mary D Sammel, Courtney A Schreiber, Sarita Sonalkar

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea H RoeDepartment of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; the Department of Biostatistics & Informatics, Colorado School of Public Health, and the Center for Innovative Design & Analysis (CIDA), Aurora, Colorado; and the Department of Obstetrics and Gynecology, University of California Davis School of Medicine, University of California, Davis, Sacramento, California.
Alice Abernathy
Anne N Flynn
Arden McAllister
Nathanael C Koelper
Mary D Sammel
Courtney A Schreiber
Sarita Sonalkar
University of California, Davis · US

Funding

WOMENS REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001265 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Howell · 1998 to 2026
$7.5M
Comparative Effectiveness of Pregnancy Failure Management Regimens (Pre-Fai-R)R01HD071920 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI SCHREIBER, COURTNEY A. · 2013 to 2017
$2.8M
NICHD NIH HHS K12 HD001265NICHD NIH HHS R01 HD071920
6 · The paper itself

Abstract

Early pregnancy loss can be treated medically with mifepristone followed by misoprostol, with ultrasonographic confirmation of pregnancy expulsion. Alternative strategies that ascertain treatment success remotely are needed. We compared percent decline in human chorionic gonadotropin (hCG) level with treatment success or failure between patients who received mifepristone pretreatment followed by misoprostol or misoprostol alone for early pregnancy loss between 5 and 12 weeks of gestation to determine a threshold decline that might predict success. Early pregnancy loss treatment success was associated with a greater percent hCG level decline compared with treatment failure, but no threshold was able to predict success. Additional research is needed to understand hCG trends after medical management of early pregnancy loss to develop reliable protocols for remote follow-up.

Indexed as

Abortifacient Agents, NonsteroidalAbortion, InducedAbortion, SpontaneousMisoprostolChorionic GonadotropinFemaleFollow-Up StudiesHumansMifepristonePregnancyAbortifacient Agents, NonsteroidalChorionic GonadotropinMifepristoneMisoprostol

Identifiers

PMID35675613
PMCPMC9181461
OpenAlexW4281710738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.