ArticleObstetrics and gynecology2022
Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy.
Article in Obstetrics and gynecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- COVID-19 Vaccine Literacy Among Black Pregnant and Postpartum Women in the USA.Journal of racial and ethnic health disparities · 2026Article
- Association of Area Deprivation Index with perinatal and COVID-19 outcomes during the early pandemic: a secondary analysis of a prospective cohort study.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025Article
- Measuring Spatial Social Polarization in Public Health Research: A Scoping Review of Methods and Applications.Journal of urban health : bulletin of the New York Academy of Medicine · 2025Article
- Impact of exposure to air pollution on cervicovaginal microbial communities.Environmental research · 2023Article
- Neighborhood Deprivation and Racial Disparities in Early Pregnancy Impaired Glucose Tolerance.International journal of environmental research and public health · 2023Article
- Pregnancy-associated morbidity and mortality during pandemics: Looking to the past in order to prepare for the future.Cell host & microbe · 2023Article
- Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design.medRxiv : the preprint server for health sciences · 2023Article
- Maternal and neonatal outcomes following SARS-CoV-2 infection.Seminars in fetal & neonatal medicine · 2023Review
- Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design.PloS one · 2023Observational
- Exploring Prenatal Care Quality and Access During the COVID-19 Pandemic Among Pregnant Immigrants in Philadelphia Through the Lens of Community-Based Organizations.Women's health reports (New Rochelle, N.Y.) · 2023Article
- Pandemic distress associated with segregation and social stressors.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo quantify the extent to which neighborhood characteristics contribute to racial and ethnic disparities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity in pregnancy.
methodsThis cohort study included pregnant patients who presented for childbirth at two hospitals in Philadelphia, Pennsylvania from April 13 to December 31, 2020. Seropositivity for SARS-CoV-2 was determined by measuring immunoglobulin G and immunoglobulin M antibodies by enzyme-linked immunosorbent assay in discarded maternal serum samples obtained for clinical purposes. Race and ethnicity were self-reported and abstracted from medical records. Patients' residential addresses were geocoded to obtain three Census tract variables: community deprivation, racial segregation (Index of Concentration at the Extremes), and crowding. Multivariable mixed effects logistic regression models and causal mediation analyses were used to quantify the extent to which neighborhood variables may explain racial and ethnic disparities in seropositivity.
resultsAmong 5,991 pregnant patients, 562 (9.4%) were seropositive for SARS-CoV-2. Higher seropositivity rates were observed among Hispanic (19.3%, 104/538) and Black (14.0%, 373/2,658) patients, compared with Asian (3.2%, 13/406) patients, White (2.7%, 57/2,133) patients, and patients of another race or ethnicity (5.9%, 15/256) (P<.001). In adjusted models, per SD increase, deprivation (adjusted odds ratio [aOR] 1.16, 95% CI 1.02-1.32) and crowding (aOR 1.15, 95% CI 1.05-1.26) were associated with seropositivity, but segregation was not (aOR 0.90, 95% CI 0.78-1.04). Mediation analyses revealed that crowded housing may explain 6.7% (95% CI 2.0-14.7%) of the Hispanic-White disparity and that neighborhood deprivation may explain 10.2% (95% CI 0.5-21.1%) of the Black-White disparity.
conclusionNeighborhood deprivation and crowding were associated with SARS-CoV-2 seropositivity in pregnancy in the prevaccination era and may partially explain high rates of SARS-CoV-2 seropositivity among Black and Hispanic patients. Investing in structural neighborhood improvements may reduce inequities in viral transmission.
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