Evidence map›Paper›PMID 35675444›Full record

ArticleJournal of neurophysiology2022

Inspiratory rhythm generation is stabilized by

Nicholas J Burgraff, Ryan S Phillips, Liza J Severs, Nicholas E Bush, Nathan A Baertsch, Jan-Marino Ramirez

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Outcompeting opioid-induced respiratory depression.Journal of thoracic disease · 2026
    Article
  3. Review
  4. Article
  5. Functional modulation of retrotrapezoid neurons drives fentanyl-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  6. Review
  7. Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicholas J BurgraffCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0001-7986-4247
Ryan S PhillipsCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0002-8570-2348
Liza J SeversCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0002-9470-8186
Nicholas E BushCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0003-0186-6394
Nathan A BaertschCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0003-1589-5575
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
University of Washington · US

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Homeostatic Plasticity of the Respiratory Rhythm Generating NetworkR00HL145004 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2021 to 2023
$747k
Homeostatic Plasticity of the Respiratory Rhythm Generating NetworkK99HL145004 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BAERTSCH, NATHAN ANDREW · 2019 to 2020
$209k
Rhythmogenic states of the respiratory network reveal differential opioid sensitivityF32HL154558 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI BURGRAFF, NICHOLAS J · 2020 to 2023
$204k
NHLBI NIH HHS F32 HL154558NHLBI NIH HHS K99 HL145004NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R00 HL145004NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389
6 · The paper itself

Abstract

Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing, a rhythmic behavior that dynamically adapts to environmental, behavioral, and metabolic changes from the first to the last breath. The pre-Bötzinger complex (preBötC), located within the ventral medulla, is responsible for producing rhythmic inspiration. Its cellular properties must be tunable, flexible as well as stabilizing. Here, we explore the role of the hyperpolarization-activated, nonselective cation current (

Indexed as

Analgesics, OpioidRespiratory InsufficiencyHumansMedulla OblongataNeuronsRespiratory CenterSynaptic TransmissionAnalgesics, OpioidbreathingIhopioidpre-Bötzinger

Identifiers

PMID35675444
PMCPMC9291429
OpenAlexW4282921115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.