Evidence map›Paper›PMID 35675425›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Intratumoral injection of schwannoma with attenuated

Sherif G Ahmed, Giulia Oliva, Manlin Shao, Xinhui Wang, John J Mekalanos, Gary J Brenner

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Deletion of themBio · 2026
    Article
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  8. Optimization Strategies and Synergistic Applications of EngineeredInternational journal of nanomedicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sherif G AhmedDepartment of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144.
Giulia OlivaDepartment of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144.
Manlin ShaoDepartment of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144.
Xinhui WangDivision of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
John J MekalanosDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
Gary J BrennerDepartment of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144.
Massachusetts General Hospital · USHarvard University · US

Funding

Prevention of post-therapy breast cancer metastasisR01CA226981 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, XINHUI · 2019 to 2023
$1.8M
Mechanisms of Caspase-1 Mediated Schwannoma RegressionR01NS081146 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRENNER, GARY JAY · 2012 to 2016
$1.8M
Salmonella typhimurium-based Bacteriotherapy for Orphan Benign Tumors: Neurofibromatosis Type II (NF2)R41NS120338 · NINDS · MULBERRY BIOTHERAPEUTICS, INC. · PI BRENNER, GARY JAY, LUO, SUSAN X · 2020 to 2021
$698k
NCI NIH HHS R01 CA226981NINDS NIH HHS R01 NS081146NINDS NIH HHS R41 NS120338
6 · The paper itself

Abstract

Schwannomas are slow-growing benign neoplasms that develop throughout the body causing pain, sensory/motor dysfunction, and death. Because bacterial immunotherapy has been used in the treatment of some malignant neoplasms, we evaluated attenuated

Indexed as

ImmunotherapyNeurilemmomaSalmonella typhimuriumAnimalsApoptosisHumansInjections, IntralesionalMiceNeoplasms, ExperimentalProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 Receptorattenuated bacterial vaccinescheckpoint blockadeSalmonella typhimuriumschwannoma

Identifiers

PMID35675425
PMCPMC9214496
OpenAlexW4282944387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.