Evidence map›Paper›PMID 35675401›Full record

ArticleScience advances2022

Isotropic three-dimensional dual-color super-resolution microscopy with metal-induced energy transfer.

Jan Christoph Thiele, Marvin Jungblut, Dominic A Helmerich, Roman Tsukanov, Anna Chizhik, Alexey I Chizhik, Martin J Schnermann, Markus Sauer, Oleksii Nevskyi, Jörg Enderlein

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  6. Mechanistic Insight into the Thermal "Blueing" of Cyanine Dyes.Journal of the American Chemical Society · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jan Christoph ThieleThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.ORCID 0000-0002-6638-6298
Marvin JungblutDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Dominic A HelmerichDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Roman TsukanovThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.ORCID 0000-0002-3967-1755
Anna ChizhikThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.ORCID 0000-0003-0454-5924
Alexey I ChizhikThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.
Martin J SchnermannChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-0503-0116
Markus SauerDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-1692-3219
Oleksii NevskyiThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.ORCID 0000-0003-2893-481X
Jörg EnderleinThird Institute of Physics-Biophysics, Georg August University, 37077 Göttingen, Germany.ORCID 0000-0001-5091-7157
University of Göttingen · DEUniversity of Würzburg · DENational Cancer Institute · US

Funding

Synthesis and evaluation of small-molecule imaging agentsZIABC011506 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNERMANN, MARTIN · 2013 to 2025
$12.1M
6 · The paper itself

Abstract

Over the past two decades, super-resolution microscopy has seen a tremendous development in speed and resolution, but for most of its methods, there exists a remarkable gap between lateral and axial resolution, which is by a factor of 2 to 3 worse. One recently developed method to close this gap is metal-induced energy transfer (MIET) imaging, which achieves an axial resolution down to nanometers. It exploits the distance-dependent quenching of fluorescence when a fluorescent molecule is brought close to a metal surface. In the present manuscript, we combine the extreme axial resolution of MIET imaging with the extraordinary lateral resolution of single-molecule localization microscopy, in particular with direct stochastic optical reconstruction microscopy (

Identifiers

PMID35675401
PMCPMC9176750
OpenAlexW4282915175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.