Evidence map›Paper›PMID 35675346›Full record

ArticlePloS one2022

Mapping HIV prevalence in Nigeria using small area estimates to develop a targeted HIV intervention strategy.

Caitlin O'Brien-Carelli, Krista Steuben, Kristen A Stafford, Rukevwe Aliogo, Matthias Alagi, Casey K Johanns, Jahun Ibrahim, Ray Shiraishi, Akipu Ehoche, Stacie Greby and 9 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Caitlin O'Brien-CarelliInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America.
Krista SteubenInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America.
Kristen A StaffordCIHEB, University of Maryland School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0001-5620-6436
Rukevwe AliogoCIHEB, MGIC-An Affiliate of the University of Maryland Baltimore, Abuja, Nigeria.
Matthias AlagiU.S. Centers for Disease Control and Prevention, Abuja, Nigeria.
Casey K JohannsInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America.
Jahun IbrahimU.S. Centers for Disease Control and Prevention, Abuja, Nigeria.
Ray ShiraishiU.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Akipu EhocheCIHEB, MGIC-An Affiliate of the University of Maryland Baltimore, Abuja, Nigeria.
Stacie GrebyU.S. Centers for Disease Control and Prevention, Abuja, Nigeria.
Emilio DirlikovU.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America.ORCID 0000-0003-4631-2643
Dalhatu IbrahimU.S. Centers for Disease Control and Prevention, Abuja, Nigeria.
Megan BronsonU.S. Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Gambo AliyuCIHEB, University of Maryland School of Medicine, Baltimore, MD, United States of America.
Sani AliyuNational Agency for the Control of AIDS, Abuja, Nigeria.
Laura Dwyer-LindgrenInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America.
Mahesh SwaminathanU.S. Centers for Disease Control and Prevention, Abuja, Nigeria.ORCID 0000-0001-5827-3245
Herbert C DuberInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States of America.
Man CharuratCIHEB, University of Maryland School of Medicine, Baltimore, MD, United States of America.ORCID 0000-0002-1719-2796

Funding

PEPFAR
6 · The paper itself

Abstract

objectiveAlthough geographically specific data can help target HIV prevention and treatment strategies, Nigeria relies on national- and state-level estimates for policymaking and intervention planning. We calculated sub-state estimates along the HIV continuum of care in Nigeria.

designUsing data from the Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS) (July-December 2018), we conducted a geospatial analysis estimating three key programmatic indicators: prevalence of HIV infection among adults (aged 15-64 years); antiretroviral therapy (ART) coverage among adults living with HIV; and viral load suppression (VLS) rate among adults living with HIV.

methodsWe used an ensemble modeling method called stacked generalization to analyze available covariates and a geostatistical model to incorporate the output from stacking as well as spatial autocorrelation in the modeled outcomes. Separate models were fitted for each indicator. Finally, we produced raster estimates of each indicator on an approximately 5×5-km grid and estimates at the sub-state/local government area (LGA) and state level.

resultsEstimates for all three indicators varied both within and between states. While state-level HIV prevalence ranged from 0.3% (95% uncertainty interval [UI]: 0.3%-0.5%]) to 4.3% (95% UI: 3.7%-4.9%), LGA prevalence ranged from 0.2% (95% UI: 0.1%-0.5%) to 8.5% (95% UI: 5.8%-12.2%). Although the range in ART coverage did not substantially differ at state level (25.6%-76.9%) and LGA level (21.9%-81.9%), the mean absolute difference in ART coverage between LGAs within states was 16.7 percentage points (range, 3.5-38.5 percentage points). States with large differences in ART coverage between LGAs also showed large differences in VLS-regardless of level of effective treatment coverage-indicating that state-level geographic targeting may be insufficient to address coverage gaps.

conclusionGeospatial analysis across the HIV continuum of care can effectively highlight sub-state variation and identify areas that require further attention in order to achieve epidemic control. By generating local estimates, governments, donors, and other implementing partners will be better positioned to conduct targeted interventions and prioritize resource distribution.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsAdultHumansNigeriaPrevalenceViral Load

Identifiers

PMID35675346
PMCPMC9176772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.