ArticleAnnals of medicine2022
Sex disparities and the risk of urolithiasis: a large cross-sectional study.
Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Global prevalence of urolithiasis: a meta-analysis accounting for methodological heterogeneity.Frontiers in urology · 2025Pooled it
- Basal metabolic rate and the risk of urolithiasis: a two-sample Mendelian randomization study.World journal of urology · 2024Pooled it
- Global, regional, and national burden of urolithiasis among children and adolescents, 1990-2021, with forecasts to 2050: a systematic analysis of the Global Burden of Disease Study 2021.World journal of urology · 2026Article
- Gender differences in long-term complications of chronic hypoparathyroidism: a systematic review.Journal of endocrinological investigation · 2026Review
- Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling.Cellular & molecular biology letters · 2026Article
- Study on metabolic differences and microbiota distribution in patients with infection-induced kidney stones by gender.BMC microbiology · 2026Article
- Comprehensive epidemiological analyses of urinary stone diseases in eastern China: a regional population-based study.BMC public health · 2026Article
- The current status and future directions of short video dissemination on urolithiasis via the TikTok platform: a cross-sectional study.Scientific reports · 2026Article
- Steroid hormones and nephrolithiasis: regulation of urine components metabolism and inflammation.Biology of sex differences · 2026Review
- Association of Body Mass Index Trajectories with Kidney Stone Disease: An Analysis Based on the NHANES Database.Kidney & blood pressure research · 2026Article
- Sex-specific signatures of gut microbiota and systemic inflammation in patients with urolithiasis: a cross-sectional study.Frontiers in cellular and infection microbiology · 2026Article
- Kidney stone disease: risk factors, pathophysiology and management.Nature reviews. Nephrology · 2025Review
- Observational
- Trends and sex disparities in the burden of urolithiasis in 204 countries and territories, 1990-2021.Chinese medical journal · 2025Article
- Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2025Article
- Temporal trends and projections of urolithiasis in China and globally from 1990 to 2030: insights from the global burden of disease study 2021.Urolithiasis · 2025Article
- Elevated Zinc and Potassium Levels in Renal Calculi Indicate Distinct Pathophysiological Mechanisms in Urolithiasis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Distribution characteristics of staghorn calculi bacteria and metabolic differences in patients of different genders.World journal of urology · 2025Article
- Associations between multiple inflammatory biomarkers and the risk of developing kidney stones.BMC urology · 2025Article
- The ratio of perirenal fat thickness to renal parenchymal thickness, a novel indicator of fat accumulation associated with kidney stones.Lipids in health and disease · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation. MATERIALS AND
methodsA total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Fully adjusted odds ratios for kidney stones were measured using restricted cubic splines. Multiple imputations was applied for missing values. Propensity score matching was utilised for sensitivity analysis.
resultsAmong the 98232 included participants, 42762 participants (43.53%) were females and 55470 participants (56.47%) were males. Patients' factors might cast an influence on the development of kidney stone disease distinctly between the two genders. A risk factor for one gender might have no effect on the other gender. The risk for urolithiasis in females continuously rises as ageing, while for males the risk presents a trend to ascend until the age of around 53 and then descend.
conclusionsPatients' factors might influence the development of kidney stones distinctly between the two genders. As age grew, the risk to develop kidney stones in females continuously ascended, while the risk in males presented a trend to ascend and then descend, which was presumably related to the weakening of the androgen signals.Key messagesWe found that patients' factors might cast an influence on the development of kidney stone disease distinctly between the two sexes.The association between age and urolithiasis presents distinct trends in the two sexesThe results will provide evidence to explore the mechanisms underlying such differences can cast light on potential therapeutic targets and promote the development of tailored therapy strategies in prospect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.