ArticlePaediatric and perinatal epidemiology2022
Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi-registry cohort study.
Article in Paediatric and perinatal epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Survival, hospitalisation and surgery in children born with Pierre Robin sequence: a European population-based cohort study.Archives of disease in childhood · 2023Pooled it
- Infant Mortality in Norway: A Population-Based Study From 2009 Through 2020.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Prevalence of major structural congenital abnormalities detected on infant surface examination in Botswana, 2014-2022: a birth outcomes surveillance study.BMJ paediatrics open · 2026Article
- Article
- Mortality amongst European children with congenital anomalies: Associations with socio-economic status in the EUROLINKCAT cohort.PloS one · 2026Observational
- Risk factors for hospital admission and length of stay for children with and without congenital anomalies: a EUROlinkCAT cohort study.BMJ paediatrics open · 2025Article
- Health outcomes and drug utilisation in children with Noonan syndrome: a European cohort study.Orphanet journal of rare diseases · 2025Article
- Hospital care in the first 10 years of life of children with congenital anomalies in six European countries: data from the EUROlinkCAT cohort linkage study.Archives of disease in childhood · 2024Article
- Educational achievement of children with selected major congenital anomalies and associated factors: a Finnish registry-based study.European journal of public health · 2023Article
- Population-based prevalence study of common congenital malformations of the alimentary tract and abdominal wall in Thailand: a study using data from the National Health Security Office.World journal of pediatric surgery · 2023Article
- Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi-registry cohort study.Paediatric and perinatal epidemiology · 2022Article
- Linking a European cohort of children born with congenital anomalies to vital statistics and mortality records: A EUROlinkCAT study.PloS one · 2021Article
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Authors and funding
36 authors at 19 institutions in 14 countries.
Funding
Abstract
backgroundCongenital anomalies are a major cause of perinatal, neonatal and infant mortality.
objectivesThe aim was to investigate temporal changes and geographical variation in survival of children with major congenital anomalies (CA) in different European areas.
methodsIn this population-based linkage cohort study, 17 CA registries members of EUROCAT, the European network for the surveillance of CAs, successfully linked data on 115,219 live births with CAs to mortality records. Registries estimated Kaplan-Meier survival at 28 days and 5 years of age and fitted Cox's proportional hazards models comparing mortality at 1 year and 1-9 years of age for children born during 2005-2014 with those born during 1995-2004. The hazard ratios (HR) from each registry were combined centrally using a random-effects model. The 5-year survival conditional on having survived to 28 days of age was calculated.
resultsThe overall risk of death by 1 year of age for children born with any major CA in 2005-2014 decreased compared to 1995-2004 (HR 0.68, 95% confidence interval [CI] 0.53, 0.89). Survival at 5 years of age ranged between registries from 97.6% to 87.0%. The lowest survival was observed for the registry of OMNI-Net (Ukraine) (87.0%, 95% CI 86.1, 87.9).
conclusionsSurvival of children with CAs improved for births in 2005-2014 compared with 1995-2004. The use of CA registry data linked to mortality data enables investigation of survival of children with CAs. Factors such as defining major CAs, proportion of terminations of pregnancy for foetal anomaly, source of mortality data and linkage methods are important to consider in the design of future studies and in the interpretation of the results on survival of children with CAs.
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