ArticleThe journal of physical chemistry letters2022
Macromolecular Regulation of the Material Properties of Biomolecular Condensates.
Article in The journal of physical chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular origins of viscoelasticity in biomolecular condensates.The Journal of chemical physics · 2026Article
- Surface-Tethering Enhances Precision in Measuring Diffusion Within 3D Protein Condensates.Journal of molecular biology · 2026Article
- Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability.bioRxiv : the preprint server for biology · 2025Article
- Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly.ACS nano · 2025Article
- Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states.Nature communications · 2025Article
- Polymeric and Polymer-Functionalized Drug Delivery Vectors: From Molecular Architecture and Elasticity to Cellular Uptake.Polymers · 2025Review
- A pH-Centric Model of Nucleolar Activity and Regulation.Journal of molecular biology · 2025Review
- Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates.Cell reports. Physical science · 2024Article
- Direct computations of viscoelastic moduli of biomolecular condensates.The Journal of chemical physics · 2024Article
- Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates.Nature physics · 2024Article
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- Amino Acid-Dependent Material Properties of Tetrapeptide Condensates.bioRxiv : the preprint server for biology · 2024Article
- Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations.Nature communications · 2024Article
- Determinants of viscoelasticity and flow activation energy in biomolecular condensates.Science advances · 2024Article
- Sequence-Dependent Material Properties of Biomolecular Codensates and their Relation to Dilute Phase Conformations.bioRxiv : the preprint server for biology · 2024Article
- Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks.Journal of the American Chemical Society · 2024Article
- ATP Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks.bioRxiv : the preprint server for biology · 2023Article
- Theoretical and Data-Driven Approaches for Biomolecular Condensates.Chemical reviews · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biomolecular condensates inside cells contain dozens to hundreds of macromolecular components and are surrounded by many others. Our computational studies predicted that macromolecular regulators have matching effects on the phase equilibrium and interfacial tension of condensates. Here we validate this prediction experimentally and characterize the effects of macromolecular regulators on other material properties, including viscoelasticity and fusion speed. Local melting due to the heating of a laser beam and turbidity assay both show that Ficoll70 raises the melting temperature of condensates formed by polylysine:heparin mixtures, whereas optical-tweezer measurements reveal parallel increases in interfacial tension. Additional optical-tweezer experiments report elevations in viscosity and shear relaxation time but also fusion speed by Ficoll70. The fusion speed is higher than predicted by modeling the condensates as purely viscous, demonstrating viscoelasticity and shear thinning. These results illustrate the ample opportunities for macromolecular regulators to tune material properties for proper functions of biomolecular condensates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.