Evidence map›Paper›PMID 35674738›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2022

CXCR4-targeted theranostics in oncology.

Andreas K Buck, Sebastian E Serfling, Thomas Lindner, Heribert Hänscheid, Andreas Schirbel, Stefanie Hahner, Martin Fassnacht, Hermann Einsele, Rudolf A Werner

Registry-linked trialAbstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557708 (Biodistribution of 68Ga Pentixafor in Patients With Small Cell Lung Carcinoma), which is not on this map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05557708 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Biodistribution of 68Ga Pentixafor in Patients With Small Cell Lung Carcinoma (SCLC)

TypeinterventionalSponsorYusuf MendaRan2026 to 2030Enrolled20ConditionsCarcinoid Tumor Lung, Neuroendocrine Tumor of the Lung, Carcinoma, Small-Cell LungArms212-Lead Pentixather, 203-Lead Pentixather SPECT/CT
3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Functional pituitary adenoma imaging.Reviews in endocrine & metabolic disorders · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. CXCR4-targeted PET imaging of glioblastoma using [EJNMMI radiopharmacy and chemistry · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Synthesis, preclinical evaluation and clinical application of a novel heterodimeric tracerEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Clinical Applications of Theranostics.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  18. Review
  19. Review
  20. Journal of neuro-oncology · 2025
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany. buck_a@ukw.de.
Sebastian E SerflingDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.
Thomas LindnerDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.
Heribert HänscheidDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.
Stefanie HahnerDivision of Endocrinology and Diabetes, Department of Medicine I, University Hospital, University of Würzburg, Wurzburg, Germany.
Martin FassnachtDivision of Endocrinology and Diabetes, Department of Medicine I, University Hospital, University of Würzburg, Wurzburg, Germany.
Hermann EinseleDepartment of Internal Medicine II, Hematology and Oncology, University Hospital Würzburg, Wurzburg, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of literature reports on the upregulation of C-X-C motif chemokine receptor 4 (CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for molecular imaging and endoradiotherapy in a theranostic setting. For instance, the CXCR4-targeting positron emission tomography (PET) agent [

Indexed as

Coordination ComplexesHematologic NeoplasmsLymphomaMultiple MyelomaAdultHumansPeptides, CyclicPrecision MedicineReceptors, CXCR4Tomography, X-Ray ComputedCoordination ComplexesCXCR4 protein, humanPeptides, CyclicReceptors, CXCR4[177Lu]PentixaTher[68Ga]PentixaFor[90Y]PentixaTherAdrenocortical carcinomaC-X-C motif chemokine receptor 4CXCR4EndoradiotherapyMultiple myelomaTheranostics

Identifiers

PMID35674738
PMCPMC9525349

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.