ArticlePlant physiology2022
CYSTEINE-RICH RECEPTOR-LIKE KINASE5 (CRK5) and CRK22 regulate the response to Verticillium dahliae toxins.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- CYSTEINE-RICH RLK2 regulates development via callose synthase-dependent symplastic transport in Arabidopsis.Plant physiology · 2026Article
- CRK5 preserves antioxidant homeostasis and prevents cell death during dark-induced senescence through inhibiting the salicylic acid signaling pathway.BMC plant biology · 2026Article
- ERF3 represses SA pathway defense to modulate tradeoffs between biotic and abiotic stress responses in Arabidopsis.Plant cell reports · 2025Article
- Salicylic acid accumulation: emerging molecular players and novel perspectives on plant development and nutrition.Journal of experimental botany · 2025Review
- More questions than answers: insights into potential cysteine-rich receptor-like kinases redox signalling in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Review
- A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants.Nature communications · 2024Article
- An expanded cysteine-rich receptor-like kinase gene cluster functionally differentiates in drought, cold, heat, and pathogen stress responses in rice.Plant biotechnology journal · 2024Article
- Genomic insights into local adaptation of upland cotton in China and Pakistan.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Transcriptomics of temperature-sensitive R gene-mediated resistance identifies a WAKL10 protein interaction network.Scientific reports · 2024Article
- An update on evolutionary, structural, and functional studies of receptor-like kinases in plants.Frontiers in plant science · 2024Review
- Genome-Wide Identification and Analysis of the WNK Kinase Gene Family in Upland Cotton.Plants (Basel, Switzerland) · 2023Article
- CaWRKY50 Acts as a Negative Regulator in Response toPlants (Basel, Switzerland) · 2023Article
- Interactions betweenFrontiers in plant science · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cysteine-rich receptor-like kinases (CRKs) play critical roles in responses to biotic and abiotic stresses. However, the molecular mechanisms of CRKs in plant defense responses remain unknown. Here, we demonstrated that two CRKs, CRK5 and CRK22, are involved in regulating defense responses to Verticillium dahliae toxins (Vd-toxins) in Arabidopsis (Arabidopsis thaliana). Biochemical and genetic analyses showed that CRK5 and CRK22 may act upstream of MITOGEN-ACTIVATED PROTEIN KINASE3 (MPK3) and MPK6 to regulate the salicylic acid (SA)-signaling pathway in response to Vd-toxins. In addition, MPK3 and MPK6 interact with the transcription factor WRKY70 to modulate defense responses to Vd-toxins. WRKY70 directly binds the promoter domains of the SA-signaling-related transcription factor genes TGACG SEQUENCE-SPECIFIC BINDING PROTEIN (TGA2) and TGA6 to regulate their expression in response to Vd-toxins. Thus, our study reveals a mechanism by which CRK5 and CRK22 regulate SA signaling through the MPK3/6-WRKY70-TGA2/6 pathway in response to Vd-toxins.
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