Evidence map›Paper›PMID 35674343›Full record

Trial reportJournal of the American Heart Association2022

Underdiagnosis and Undertreatment of Modifiable Cardiovascular Risk Factors Among Survivors of Childhood Cancer.

Eric J Chow, Yan Chen, Gregory T Armstrong, Laura-Mae Baldwin, Casey R Cai, Todd M Gibson, Melissa M Hudson, Aaron McDonald, Paul C Nathan, Jeffrey E Olgin and 4 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Recent updates and perspectives in "Onco-hypertension".Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  7. Article
  8. Management of late toxicities and specific follow-up needs of adolescent and young adult cancer survivors: recommendations from scientific societies in Spain.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Eric J ChowPublic Health Sciences and Clinical Research Divisions Fred Hutchinson Cancer Research Center Seattle WA.ORCID 0000-0001-7712-961X
Yan ChenUniversity of Alberta Edmonton Alberta Canada.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN.
Laura-Mae BaldwinDepartment of Family Medicine University of Washington Seattle WA.
Casey R CaiSchool of Medicine University of Texas Southwestern Dallas TX.ORCID 0000-0002-8256-8614
Todd M GibsonDivision of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD.
Melissa M HudsonDepartment of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN.
Aaron McDonaldDepartment of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN.
Paul C NathanDepartment of Pediatrics The Hospital for Sick Children University of Toronto Ontario Canada.
Jeffrey E OlginDivision of Cardiology Department of Medicine University of California San Francisco CA.ORCID 0000-0003-1684-9327
Karen L SyrjalaPublic Health Sciences and Clinical Research Divisions Fred Hutchinson Cancer Research Center Seattle WA.
Emily S TonorezosDivision of Cancer Control and Population Science National Cancer Institute Rockville MD.ORCID 0000-0002-1185-5210
Kevin C OeffingerDepartment of Medicine Duke University Durham NC.
Yutaka YasuiUniversity of Alberta Edmonton Alberta Canada.ORCID 0000-0002-7717-8638
St. Jude Children's Research Hospital · USNational Cancer Institute · USDuke University · USFred Hutch Cancer Center · USSeattle Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Alberta · CAUniversity of California, San Francisco · USUniversity of Toronto · CAUniversity of Washington · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
The Health ePeople Resource for Mobilized ResearchU2CEB021881 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCUS, GREGORY M, OLGIN, JEFFREY E · 2015 to 2020
$10.3M
Improving treatment of cardiovascular risk factors in childhood cancer survivorsR01CA204378 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHOW, ERIC JESSEN · 2017 to 2021
$3.7M
Predicting and Preventing Chemotherapy-InducedCardiotoxicity in African American ChildrenR01CA261898 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BURRIDGE, PAUL W., SAPKOTA, YADAV · 2021 to 2025
$3.6M
Late Effects Prediction using Clinical Phenotypes and Whole Genome SequencingR01CA216354 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YASUI, YUTAKA, ZHANG, JINGHUI · 2017 to 2021
$3.4M
NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA204378NCI NIH HHS R01 CA216354NCI NIH HHS U01 CA195547NCI NIH HHS U24 CA055727NIBIB NIH HHS U2C EB021881
6 · The paper itself

Abstract

Background Determine the prevalence and predictors associated with underdiagnosis and undertreatment of modifiable cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, glucose intolerance/diabetes) among adult survivors of childhood cancer at high risk of premature CVD. Methods and Results This was a cross-sectional study of adult-aged survivors of childhood cancer treated with anthracyclines or chest radiotherapy, recruited across 9 US metropolitan regions. Survivors completed questionnaires and in-home clinical assessments. The comparator group was a matched sample from the National Health and Nutrition Examination Survey. Multivariable logistic regression estimated the risk (odds ratios) of CVD risk factor underdiagnosis and undertreatment among survivors compared with the National Health and Nutrition Examination Survey. Survivors (n=571; median age, 37.7 years and 28.5 years from cancer diagnosis) were more likely to have a preexisting CVD risk factor than the National Health and Nutrition Examination Survey (n=345;

Indexed as

Cancer SurvivorsCardiovascular DiseasesDyslipidemiasHypertensionNeoplasmsAdultAgedChildCross-Sectional StudiesHeart Disease Risk FactorsHumansMaleNutrition SurveysPrevalenceRisk FactorsSurvivorscancer survivorscardiovascular risk factorundertreatment

Identifiers

PMID35674343
PMCPMC9238650
OpenAlexW4282922101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.