Evidence map›Paper›PMID 35674284›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study.

Omar Al-Louzi, Sargis Manukyan, Maxime Donadieu, Martina Absinta, Vijay Letchuman, Brent Calabresi, Parth Desai, Erin S Beck, Snehashis Roy, Joan Ohayon and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Reply.AJNR. American journal of neuroradiology · 2024
    Article
  5. Review
  6. A Novel Convolutional Neural Network for Automated Multiple Sclerosis Brain Lesion Segmentation.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Review
  7. Paramagnetic rim lesions and the central vein sign: Characterizing multiple sclerosis imaging markers.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Omar Al-LouziTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-2260-5660
Sargis ManukyanTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Maxime DonadieuTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Martina AbsintaTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD; USA/IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0003-0276-383X
Vijay LetchumanTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Brent CalabresiTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Parth DesaiDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Erin S BeckTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7839-7958
Snehashis RoySection on Neural Function, National Institute of Mental Health, Bethesda, MD, USA.
Joan OhayonNeuroimmunology Clinic, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Dzung L PhamCenter for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Anish ThomasDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Steven JacobsonViral Immunology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Irene CorteseNeuroimmunology Clinic, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Pavan K AuluckHuman Brain Collection Core, National Institute of Mental Health, Bethesda, MD, USA.
Govind NairTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Pascal SatiTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-6763-0125
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0002-2628-4334

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Immunologic Mechanisms In Experimental Autoimmune Diseases Of The Nervous SystemZIANS002204 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$8.5M
NINDS Quantitative MRI Core FacilityZICNS009438 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NAIR, GOVIND · 2022 to 2025
$4.3M
Intramural NIH HHS ZIA NS003119Intramural NIH HHS ZIA NS003148
6 · The paper itself

Abstract

backgroundThe "central vein sign" (CVS), a linear hypointensity on T2*-weighted imaging corresponding to a central vein/venule, is associated with multiple sclerosis (MS) lesions. The effect of lesion-size exclusion criteria on MS diagnostic accuracy has not been extensively studied.

objectiveInvestigate the optimal lesion-size exclusion criteria for CVS use in MS diagnosis.

methodsCross-sectional study of 163 MS and 51 non-MS, and radiological/histopathological correlation of 5 MS and 1 control autopsy cases. The effects of lesion-size exclusion on MS diagnosis using the CVS, and intralesional vein detection on histopathology were evaluated.

resultsCVS+ lesions were larger compared to CVS- lesions, with effect modification by MS diagnosis (mean difference +7.7 mm

conclusionLesion-size measures add important information when using CVS+ lesion counts for MS diagnosis. The CVS is a specific biomarker corresponding to intralesional veins on histopathology.

Indexed as

Multiple SclerosisBrainCross-Sectional StudiesHumansMagnetic Resonance ImagingVeinsBiomarkerscentral vein signmagnetic resonance imagingmultiple sclerosispost mortemT2 lesions

Identifiers

PMID35674284
PMCPMC9489648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.