SynthesisSchizophrenia bulletin2022
Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.
Synthesis in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Global lifetime prevalence of schizophrenia: A systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- Joint effects of childhood adversity and genetic risk for psychosis on psychopathology in the UK Biobank.Psychological medicine · 2026Article
- Genetic Risk, Self-Harm, and Violence in Schizophrenia: A Narrative Review of Implications for Early Identification and Intervention.Clinical neuropsychiatry · 2025Review
- The PAthways to Resilience And Mental health (PARAM) project: protocol for a multi-site developmental cohort in India.BMC psychiatry · 2025Article
- Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- The relationship between lifetime trauma exposure and psychosis in a multi-country case-control study in Africa.SSM. Mental health · 2025Article
- A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing.Diagnostics (Basel, Switzerland) · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.Translational psychiatry · 2024Article
- Relationships between trauma types and psychotic symptoms: A network analysis of patients with psychotic disorders in a large, multi-country study in East Africa.Comprehensive psychiatry · 2024Article
- Serious mental health conditions and exposure to adulthood trauma in low- and middle-income countries: a scoping review.Global mental health (Cambridge, England) · 2024Article
- Considerations, Caveats, and Suggestions for the Use of Polygenic Scores for Social and Behavioral Traits.Behavior genetics · 2024Review
- Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review.Frontiers in psychiatry · 2024Review
- Reported race-associated differences in control and schizophrenia post-mortem brain transcriptomes implicate stress-related and neuroimmune pathways.Frontiers in molecular neuroscience · 2024Article
- Childhood Trauma and Self-harm in Youths with Bipolar Disorders.Current neuropharmacology · 2024Article
- Urbanicity and psychotic disorders: Facts and hypotheses.Dialogues in clinical neuroscience · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and hypothesisSchizophrenia has been robustly associated with multiple genetic and environmental risk factors. Childhood adversity is one of the most widely replicated environmental risk factors for schizophrenia, but it is unclear if schizophrenia genetic risk alleles contribute to this association. STUDY
designIn this systematic review and meta-analysis, we assessed the evidence for gene-environment correlation (genes influence likelihood of environmental exposure) between schizophrenia polygenic risk score (PRS) and reported childhood adversity. We also assessed the evidence for a gene-environment interaction (genes influence sensitivity to environmental exposure) in relation to the outcome of schizophrenia and/or psychosis. This study was registered on PROSPERO (CRD42020182812). Following PRISMA guidelines, a search for relevant literature was conducted using Cochrane, MEDLINE, PsycINFO, Web of Science, and Scopus databases until February 2022. All studies that examined the association between schizophrenia PRS and childhood adversity were included. STUDY
resultsSeventeen of 650 identified studies met the inclusion criteria and were assessed against the Newcastle-Ottawa Scale for quality. The meta-analysis found evidence for gene-environment correlation between schizophrenia PRS and childhood adversity (r = .02; 95% CI = 0.01, 0.03; P = .001), but the effect was small and therefore likely to explain only a small proportion of the association between childhood adversity and psychosis. The 4 studies that investigated a gene-environment interaction between schizophrenia PRS and childhood adversity in increasing risk of psychosis reported inconsistent results.
conclusionsThese findings suggest that a gene-environment correlation could explain a small proportion of the relationship between reported childhood adversity and psychosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.