Evidence map›Paper›PMID 35673999›Full record

ArticleExperimental neurobiology2022

Time Course of Remote Neuropathology Following Diffuse Traumatic Brain Injury in the Male Rat.

Katherine R Giordano, L Matthew Law, Jordan Henderson, Rachel K Rowe, Jonathan Lifshitz

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Katherine R GiordanoBARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85013, USA.
L Matthew LawBARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85013, USA.
Jordan HendersonBARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85013, USA.
Rachel K RoweDepartment of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Jonathan LifshitzBARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85013, USA.
University of Arizona · USPhoenix Children's Hospital · USPhoenix VA Health Care System · USUniversity of Colorado Boulder · US

Funding

Precision Identification and Targeting of Rod Microglia in Diffuse Brain-Injured CortexF31NS113408 · NINDS · UNIVERSITY OF ARIZONA · PI GIORDANO, KATHERINE R · 2020 to 2022
$120k
NINDS NIH HHS F31 NS113408RRD VA I01 RX002472RRD VA I01 RX002691
6 · The paper itself

Abstract

Traumatic brain injury (TBI) can affect different regions throughout the brain. Regions near the site of impact are the most vulnerable to injury. However, damage to distal regions occurs. We investigated progressive neuropathology in the dorsal hippocampus (near the impact) and cerebellum (distal to the impact) after diffuse TBI. Adult male rats were subjected to midline fluid percussion injury or sham injury. Brain tissue was stained by the amino cupric silver stain. Neuropathology was quantified in sub-regions of the dorsal hippocampus at 1, 7, and 28 days post-injury (DPI) and coronal cerebellar sections at 1, 2, and 7 DPI. The highest observed neuropathology in the dentate gyrus occurred at 7 DPI which attenuated by 28 DPI, whereas the highest observed neuropathology was at 1 DPI in the CA3 region. There was no significant neuropathology in the CA1 region at any time point. Neuropathology was increased at 7 DPI in the cerebellum compared to shams and stripes of pathology were observed in the molecular layer perpendicular to the cerebellar cortical surface. Together these data show that diffuse TBI can result in neuropathology across the brain. By describing the time course of pathology in response to TBI, it is possible to build the temporal profile of disease progression.

Indexed as

CerebellumDiffuse axonal injuryHippocampusNeuropathologySilver stainTraumatic brain injury

Identifiers

PMID35673999
PMCPMC9194637
OpenAlexW4281636985

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.