Evidence map›Paper›PMID 35673942›Full record

ArticleActa obstetricia et gynecologica Scandinavica2022

Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population-based cohort study.

Linda Kujanpää, Riikka K Arffman, Paula Pesonen, Elisa Korhonen, Salla Karjula, Marjo-Riitta Järvelin, Stephen Franks, Juha S Tapanainen, Laure Morin-Papunen, Terhi T Piltonen

Open access · diamondAbstract read
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Review
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  8. Article
  9. Review
  10. Article
  11. Polycystic ovary syndrome.Nature reviews. Disease primers · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Mitochondrial Dysfunction in Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Linda KujanpääPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0003-2849-9432
Riikka K ArffmanPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0003-3277-9293
Paula PesonenInfrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-4215-3430
Elisa KorhonenPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0002-1030-4417
Salla KarjulaPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0003-3908-0418
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-2149-0630
Stephen FranksInstitute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Juha S TapanainenPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0002-3139-9128
Laure Morin-PapunenPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0001-5987-7534
Terhi T PiltonenPEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), University of Oulu, Oulu, Finland.ORCID 0000-0002-9921-7300
Oulu University Hospital · FIImperial College London · GBUniversity of Helsinki · FIUniversity of Oulu · FI

Funding

Medical Research Council G0802782Medical Research Council MR/S019669/1
6 · The paper itself

Abstract

introductionThis population-based follow-up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. MATERIAL AND

methodsThe study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years (n = 246) and controls without PCOS symptoms or diagnosis (n = 1573), referred to as non-PCOS women. The main outcome measures were self-reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years.

resultsOverall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16-1.57) and medication use by 27% [RR 1.27, 95% CI 1.08-1.50) compared with non-PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index.

conclusionsWomen with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index.

Indexed as

Polycystic Ovary SyndromeAdultBody Mass IndexCohort StudiesFemaleFollow-Up StudiesHumansMiddle AgedMultimorbiditycohort studycomorbiditymedication usemultimorbiditypolycystic ovary syndrome

Identifiers

PMID35673942
PMCPMC9564432
OpenAlexW4281781792

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.