Evidence map›Paper›PMID 35673924›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Interleukin-17A is closely correlated with the progression of renal epithelial-mesenchymal transition in spontaneously hypertensive rats].

M Xiang, Y Wang, R Mei, J Fu, J Chen, C DU

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M XiangDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
Y WangDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
R MeiDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
J FuDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
J ChenDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
C DUDepartment of Medical Functional Sciences, Medical College of Anhui University of Science & Technology, Huainan 232001, China.
Anhui University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of interleukin-17A (IL-17A) in renal epithelial- mesenchymal transition (EMT) in essential hypertensive nephropathy.

methodsFour-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats (control group) were both randomized into 4 groups (

resultsAt the age of 6 weeks, the SHRs began to show significantly higher blood pressure with greater Th17 cell percentage in the splenocytes and high renal expression and plasma level of IL-17A than WKY rats (

conclusionIL-17A is closely correlated with the progression of renal EMT in SHR and plays its role possibly by mediating M1/M2 polarization of renal infiltrating macrophages.

Indexed as

HypertensionInterleukin-17AnimalsBlood PressureCadherinsEpithelial-Mesenchymal TransitionKidneyRatsRats, Inbred SHRRats, Inbred WKYRNA, MessengerCadherinsInterleukin-17RNA, Messengerepithelial-mesenchymal transitionhigh blood pressureinterleukin-17Amacrophages

Identifiers

PMID35673924
PMCPMC9178642
OpenAlexW4282925021

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.