ArticleJournal of the Royal Society, Interface2022
Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing.
Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Active deformation in the basal organ of Corti in gerbil.Biophysical journal · 2026Article
- Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell.Structure (London, England : 1993) · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements.Hearing research · 2025Article
- Article
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- A parametric blueprint for optimum cochlear outer hair cell design.Journal of the Royal Society, Interface · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell membrane. In the present report, electrical power consumption and mechanical power output of the OHC membrane-motor complex are determined using previously published voltage-clamp data from isolated OHCs and membrane patches. Results reveal that power output peaks at a best frequency much higher than implied by the low-pass character of nonlinear capacitance, and much higher than the whole-cell resistive-capacitive corner frequency. High frequency power output is enabled by a -90° shift in the phase of electrical charge displacement in the membrane, manifested electrically as emergence of imaginary-valued nonlinear capacitance.
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