Observational studyArthritis & rheumatology (Hoboken, N.J.)2022
Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals With Knee Osteoarthritis: Data From the Osteoarthritis Initiative Cohort.
Observational study in Arthritis & rheumatology (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-Based Dietary Practices to Improve Osteoarthritis Symptoms: An Umbrella Review.Nutrients · 2023Pooled it
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Multi-omics reveals molecular signatures of moderate intensity exercise and identifies candidate exercise mimetics in mice.Redox biology · 2026Article
- Causal relationship between BMI-mediated different modes of transportation and risk of osteoarthritis: a Mendelian randomization and mediation analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Knee muscle strength as a mediator of sex differences in incident knee osteoarthritis.Arthritis research & therapy · 2026Article
- Dampened inflammation and reduced risk of osteoarthritis among non-industrialized societies.Osteoarthritis and cartilage · 2026Review
- Walking is the form of physical activity people with osteoarthritis in the hip or knee choose and maintain after two years.Osteoarthritis and cartilage open · 2025Article
- Article
- A Catalog of "Knee Friendly" Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey.ACR open rheumatology · 2025Article
- Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis.Aging clinical and experimental research · 2025Article
- Effects of Aquatic Exercise in Older People with Osteoarthritis: Systematic Review of Randomized Controlled Trials.Geriatrics (Basel, Switzerland) · 2025Review
- Neighborhood Characteristics and Walking Behavior Among Adults With Arthritis: A National Health Interview Survey Study.Arthritis care & research · 2025Article
- Optimal exercise modalities and doses for therapeutic management of osteoarthritis of the knee.Frontiers in aging · 2025Review
- Genetic causal relationship between physical activity and osteoarthritis: a two-sample Mendelian randomization study.Archives of medical science : AMS · 2025Article
- Association of physical activity trajectories over 8 years and risk of knee replacement: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression.Scientific reports · 2024Observational
- Knee osteoarthritis pendulum therapy:Journal of orthopaedic translation · 2024Article
- Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis.Clinical interventions in aging · 2024Review
- Role and Mechanism of Mechanical Load in the Homeostasis of the Subchondral Bone in Knee Osteoarthritis: A Comprehensive Review.Journal of inflammation research · 2024Review
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13 authors.
Funding
Abstract
objectiveTo assess the relationship between walking for exercise and symptomatic and structural disease progression in individuals with knee osteoarthritis (OA).
methodsWe assessed a nested cohort of participants age 50 years or older within the Osteoarthritis Initiative, a community-based observational study in which subjects were enrolled between 2004 and 2006. We focused on 4 dichotomous outcomes from baseline to the 48-month visit, involving determination of the frequency of knee pain and radiographic severity of knee OA on posteroanterior semiflexed knee radiographs. The outcomes assessed included 1) new frequent knee pain, 2) worsening of radiographic severity of knee OA based on the Kellgren/Lawrence grade, 3) progression of medial joint space narrowing, and 4) improved frequent knee pain. We used a modified version of the Historical Physical Activity Survey Instrument to ascertain those subjects who reported walking for exercise after age 50 years. The survey was administered at the 96-month visit (2012-2014).
resultsOf 1,212 participants with knee OA, 45% were male and 73% reported walking for exercise. The mean ± SD age was 63.2 ± 7.9 years, and the mean ± SD body mass index was 29.4 ± 4.6 kg/m
conclusionIn individuals with knee OA who were age 50 years or older, walking for exercise was associated with less frequent development of knee pain. These findings support the notion that walking for exercise should be encouraged for people with knee OA. Furthermore, we offer a proof of concept that walking for exercise could be disease modifying, which warrants further study.
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