Evidence map›Paper›PMID 35673765›Full record

ArticleRespirology (Carlton, Vic.)2022

Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts.

Stephany Sánchez-Ovando, Stelios Pavlidis, Nazanin Zounemat Kermani, Katherine Joanne Baines, Daniel Barker, Peter G Gibson, Lisa G Wood, Ian M Adcock, Kian Fan Chung, Jodie Louise Simpson and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respirology (Carlton, Vic.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. KIF1B Regulates NLRP3-Mediated Pyroptosis in Asthma Progression.Journal of cellular and molecular medicine · 2025
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Stephany Sánchez-OvandoPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0003-1389-2506
Stelios PavlidisData Science Institute, Imperial College London, London, UK.ORCID 0000-0001-9435-6064
Nazanin Zounemat KermaniData Science Institute, Imperial College London, London, UK.
Katherine Joanne BainesPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-4240-6581
Daniel BarkerFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Peter G GibsonPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0001-5865-489X
Lisa G WoodPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-0941-9225
Ian M AdcockNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-2101-8843
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-7101-1426
Jodie Louise SimpsonPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-3626-680X
Peter A B WarkPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0001-5676-6126
University of Newcastle Australia · AUImperial College London · GBJohn Hunter Hospital · AUNIHR Imperial Biomedical Research Centre · GB

Funding

Medical Research Council MR/T010371/1Wellcome Trust 093080/Z/10/Z
6 · The paper itself

Abstract

BACKGROUND AND

objectiveSevere asthma (SA) is a heterogeneous disease. Transcriptomic analysis contributes to the understanding of pathogenesis necessary for developing new therapies. We sought to identify and validate mechanistic pathways of SA across two independent cohorts.

methodsTranscriptomic profiles from U-BIOPRED and Australian NOVocastrian Asthma cohorts were examined and grouped into SA, mild/moderate asthma (MMA) and healthy controls (HCs). Differentially expressed genes (DEGs), canonical pathways and gene sets were identified as central to SA mechanisms if they were significant across both cohorts in either endobronchial biopsies or induced sputum.

resultsThirty-six DEGs and four pathways were shared across cohorts linking to tissue remodelling/repair in biopsies of SA patients, including SUMOylation, NRF2 pathway and oxidative stress pathways. MMA presented a similar profile to HCs. Induced sputum demonstrated IL18R1 as a shared DEG in SA compared with healthy subjects. We identified enrichment of gene sets related to corticosteroid treatment; immune-related mechanisms; activation of CD4

conclusionOur results identified differentially expressed pathways that highlight the role of CD4

Indexed as

Airway RemodelingAsthmaAustraliaHumansInflammationNF-E2-Related Factor 2SputumTranscriptomeNF-E2-Related Factor 2airway remodellingbiopsiesgene expressioninflammationpathogenesissevere asthmasputumtranscriptome

Identifiers

PMID35673765
PMCPMC9540453
OpenAlexW4281985492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.