ArticleCNS neuroscience & therapeutics2022
Gray and white matter alterations in different predominant side and type of motor symptom in Parkinson's disease.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive function in different motor subtypes of Parkinson's disease: A systematic review and multilevel meta-analysis.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Identifing two distinct cortical progression subtypes of Parkinson's disease through multimodal neuroimaging.European journal of nuclear medicine and molecular imaging · 2026Article
- Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.Brain communications · 2026Article
- Gray matter alterations in tremor-dominant Parkinson's disease after MRgFUS thalamotomy are correlated with tremor improvement: a pilot study.Quantitative imaging in medicine and surgery · 2023Article
- Review
- Gray and white matter alterations in different predominant side and type of motor symptom in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review.Frontiers in aging neuroscience · 2022Review
- Surgery for Obsessive-Compulsive Disorder and Transient Tremors as Newly Reported Side Effect: First Psychiatric Neurosurgery in Egypt.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is highly heterogeneous reflected by different affected side of body and type of motor symptom. We aim to explore clinical characteristics and underlying brain structure alterations in PD with different predominant sides and motor types.
methodsWe recruited 161 PD patients and 50 healthy controls (HC). Patients were classified into four subtypes according to their predominant side and motor type: left akinetic/rigid-dominant (LAR), left tremor-dominant (LTD), right akinetic/rigid-dominant (RAR), and right tremor-dominant (RTD). All participants assessed motor and cognitive performances, then underwent T1-weighted and diffusion tensor imaging scanning. A general linear model was used to compare neuroimaging parameters among five groups.
resultsAmong four PD subtypes, patients of LAR subtype experienced the worst motor impairment, and only this subtype showed worse cognitive performance compared with HC. Compared with HC and other subtypes, LAR subtype showed a significant reduction in cortical thickness of the right caudal-anterior-cingulate gyrus and fractional anisotropy of the right cingulum bundle.
conclusionsWe demonstrated that LAR subtype had the worst clinical performance, which the severer damage in the right cingulate region might be the underlying mechanism. This study underscores the importance of classifying PD subtypes based on both the side and type of motor symptom for clinical intervention and research to optimize behavioral outcomes in the future.
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