ArticleTheranostics2022
Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition.
Open access · goldAbstract read
In one paragraph
Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- The Role and Mechanism of Endothelial Progenitor Cell-Derived Extracellular Vesicles in Vascular Repair of Ischemic Heart Disease.Journal of cardiovascular translational research · 2026Review
- Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes.Acta pharmacologica Sinica · 2026Review
- Endothelial progenitor cell derived extracellular vesicles promotes wound healing in diabetic mice via activating mobilization and neovascularization.Cell biology and toxicology · 2026Article
- Extracellular vesicles and acetylation: reciprocal regulation in disease progression.Frontiers in immunology · 2026Review
- Muscle-specific miR-499-5p delivered by small extracellular vesicles impairs endothelial function and ischemic hindlimb recovery in diabetic mice.Cardiovascular diabetology · 2025Article
- Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.Applied biochemistry and biotechnology · 2025Article
- Review
- Extracellular Vesicles as Mediators of Endothelial Dysfunction in Cardiovascular Diseases.International journal of molecular sciences · 2025Review
- Empagliflozin-Pretreated MSC-Derived Exosomes Enhance Angiogenesis and Wound Healing via PTEN/AKT/VEGF Pathway.International journal of nanomedicine · 2025Article
- Multi-omics analysis of small extracellular vesicles in osteoarthritis: bridging the gap between molecular insights and clinical applications.Burns & trauma · 2025Review
- Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity.Burns & trauma · 2025Review
- Histone Deacetylase Inhibitors as a Promising Treatment Against Myocardial Infarction: A Systematic Review.Journal of clinical medicine · 2024Review
- Adipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes.Lipids in health and disease · 2024Review
- GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation.iScience · 2024Article
- Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications.Journal of translational medicine · 2024Review
- Epigenetic regulation of sex dimorphism in cardiovascular health.Canadian journal of physiology and pharmacology · 2024Review
- Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure.Circulation research · 2024Article
- Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases.Cell & bioscience · 2024Review
- Chromatin modifiers in human disease: from functional roles to regulatory mechanisms.Molecular biomedicine · 2024Review
- Epigenetics in diabetic cardiomyopathy.Clinical epigenetics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Grace HuangCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Zhongjian ChengCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Alycia HildebrandCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Chunlin WangCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Maria CiminiCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Rakija RoyCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Anna Maria LuccheseCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Cindy BenedictCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Vandana MallaredyCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Ajit MagadumCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Darukeshwara JoladarashiCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Charan ThejCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Carolina GonzalezCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
May TrungcaoCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Venkata Naga Srikanth GarikipatiDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210.
John W ElrodCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Walter J KochCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Raj KishoreCenter for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140.
Temple University · USThe Ohio State University Wexner Medical Center · US
Funding
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0MTargeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4MTNF mRNA stability and restenosisR01HL091983 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2009 to 2022
$5.3MRestoration of myocardial reparative function of diabetic progenitor cells by epigenetic modulationR01HL143892 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2020 to 2023
$2.2MNHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL091983NHLBI NIH HHS R01 HL143892
Abstract
PubMed holds no abstract for this paper.
Indexed as
Diabetes MellitusEndothelial Progenitor CellsExtracellular VesiclesMyocardial InfarctionAnimalsHistonesHumansMiceMyocytes, CardiacSOXC Transcription FactorsHistonesSOX12 protein, humanSOXC Transcription FactorsAngiogenesisCardiac injuryEndothelial progenitorsExtracellular vesicleHistone acetylation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.