Evidence map›Paper›PMID 35673563›Full record

ArticleTheranostics2022

Grafted human ESC-derived astroglia repair spinal cord injury via activation of host anti-inflammatory microglia in the lesion area.

Jian Wang, Peng Jiang, Wenbin Deng, Yuhui Sun, Yaobo Liu

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  4. SGK1 upregulation in GFAPCell death & disease · 2025
    Article
  5. Review
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  12. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jian WangJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University; Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China.
Peng JiangDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States.
Wenbin DengSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 518000, China.
Yuhui SunJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University; Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China.
Yaobo LiuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University; Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China.
Rutgers, The State University of New Jersey · USSecond Affiliated Hospital of Soochow University · CNShanghai Tenth People's Hospital · CNSoochow University · CN

Funding

Novel Functions of OLIG2 in Regulating Human Interneuron Production in Health and DiseaseR01NS102382 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI JIANG, PENG · 2018 to 2022
$1.6M
NINDS NIH HHS R01 NS102382
6 · The paper itself

Abstract

Grafted astroglia/astrocytes exhibit neuroprotective effects and improve functional recovery after injury to the central nervous system. This study sought to elucidate their ability to repair spinal cord lesions and the underlying mechanisms.

Indexed as

AstrocytesSpinal Cord InjuriesAnimalsAnti-Inflammatory AgentsAxonsHumansInterleukin-4MiceMicrogliaNerve RegenerationAnti-Inflammatory AgentsInterleukin-4anti-inflammatory shift of microgliaastroglial transplantationaxon regenerationfunctional recoveryscar formation

Identifiers

PMID35673563
PMCPMC9169351
OpenAlexW4285185629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.