ArticleJournal of diabetes and metabolic disorders2022
Investigation of expression of myocardial miR-126, miR-29a and miR-222 as a potential marker in STZ- induced diabetic rats following interval and continuous exercise training.
Article in Journal of diabetes and metabolic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Different types of exercise and myocardial angiogenesis regulation: A scoping review of cardiac-specific evidence in animal models.Physiological reports · 2026Article
- Rosmanol Alleviates Myocardial Ischemia-Reperfusion Injury by Enhancing the Myocardial miR-126/VEGF/PI3K/AKT Signaling in STZ-Induced Diabetic Rats.Combinatorial chemistry & high throughput screening · 2025Article
- Cardioepigenetics in action: aerobic exercise-induced modulation of miRNAs, lncRNAs, and chromatin remodeling in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
- MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training.American journal of physiology. Heart and circulatory physiology · 2024Review
- Acute Effects of Serial and Integrated Concurrent Exercise on Circulating microRNAs -126 and -222 in Sedentary Adults.International journal of exercise science · 2024Article
- Cardiac angiogenesis enhances by activating Mir-126 and related target proteins in type 2 diabetic rats: Rescue combination effect of Sodium butyrate and voluntary exercise therapy.Journal of diabetes and metabolic disorders · 2023Article
- Roles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetes.Diabetology & metabolic syndrome · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Cardiac miRNAs are the recently discovered key modulators of gene expression in the heart which have been shown to contribute to both transcriptional and post-transcriptional regulation in diabetic cardiomyopathy. The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes. Methods: Thirty male wistar rats (200 ± 20 g) were randomly divided into six groups of healthy control (HC), diabetes control (DC), continuous training (CT), interval training (IT), continuous training with diabetes (CTD), and interval training with diabetes (ITD). Nicotinamide and Streptozotocin (STZ) were injected to induce type 2 diabetes. CT was performed with a speed of 10 to 22 m/min and 20 to 30 min and IT was performed with 10 to 39 m/min and total time of 15 min, five sessions per week for 6 weeks. Muscle expression of miR-126, miR-29a and miR-222 was determined by the RT-PCR method. Results: The results show that gene expression of miR-126 was higher in IT ( Conclusion: Diabetes decreased the expression of genes associated with the development of cardiac function. It seems that IT played a more effective role in cardiac protection than CT through higher miR-126, miR-222 and miR-29a gene expression.
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