Evidence map›Paper›PMID 35672826›Full record

ArticleJournal of nanobiotechnology2022

3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence.

Wentao Dang, Wei-Chih Chen, Enguo Ju, Yanteng Xu, Kai Li, Haixia Wang, Kun Wang, Shixian Lv, Dan Shao, Yu Tao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 60 citations in OpenAlex.

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  8. Organoids technology in cancer research: from basic applications to advancedFrontiers in cell and developmental biology · 2025
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  17. Smart nanogels for cancer treatment from the perspective of functional groups.Frontiers in bioengineering and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Wentao Dang *Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Wei-Chih Chen *Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Enguo Ju *Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. jueng@mail.sysu.edu.cn.
Yanteng XuLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Kai LiDepartment of Ultrasound, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Haixia WangLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Kun WangDepartment of Joint and Trauma Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. wangk@mail.sysu.edu.cn.
Shixian LvSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Dan ShaoInstitutes of Life Sciences, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, 510006, China.
Yu TaoLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. taoy28@mail.sysu.edu.cn.
Mingqiang LiLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. limq567@mail.sysu.edu.cn.
Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CNKey Laboratory of Guangdong Province · CNPeking University · CNSouth China University of Technology · CN

Funding

China Postdoctoral Science Foundation 2019TQ0364Guangdong Provincial Pearl River Talents Program 2019QN01Y131Guangdong Provincial Science and Technology Program 2018A050506035National Key Research and Development Program of China 2019YFA0111300National Natural Science Foundation of China 21907113National Natural Science Foundation of China 32001012National Natural Science Foundation of China 51903256National Natural Science Foundation of China 81772368Science and Technology Planning Project of Guangdong Province 2017B090912007Science and Technology Program of Guangzhou 202102010217Science and Technology Program of Guangzhou 202102010225
6 · The paper itself

Abstract

Surgical resection to achieve tumor-free margins represents a difficult clinical scenario for patients with hepatocellular carcinoma. While post-surgical treatments such as chemotherapy and radiotherapy can decrease the risk of cancer recurrence and metastasis, growing concerns about the complications and side effects have promoted the development of implantable systems for locoregional treatment. Herein, 3D printed hydrogel scaffolds (designed as Gel-SA-CuO) were developed by incorporating one agent with multifunctional performance into implantable devices to simplify the fabrication process for efficiently inhibiting postoperative tumor recurrence. CuO nanoparticles can be effectively controlled and sustained released during the biodegradation of hydrogel scaffolds. Notably, the released CuO nanoparticles not only function as the reservoir for releasing Cu

Indexed as

FerroptosisLiver NeoplasmsNanoparticlesCell Line, TumorGlutathioneHumansHydrogelsNeoplasm Recurrence, LocalPrinting, Three-DimensionalGlutathioneHydrogels3D printingChemodynamic therapyFerroptosisHydrogel scaffoldsTumor recurrence

Identifiers

PMID35672826
PMCPMC9171966
OpenAlexW4281703627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.